PMID- 21273391
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211020
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Sep
TI  - Comparison of cardiac and pulmonary-specific quality-of-life measures in 
      pulmonary arterial hypertension.
PG  - 608-16
LID - 10.1183/09031936.00161410 [doi]
AB  - Studies systematically comparing the performance of health-related 
      quality-of-life (HRQoL) instruments in pulmonary arterial hypertension (PAH) are 
      lacking. We sought to address this by comparing cardiac and respiratory-specific 
      measures of HRQoL in PAH. We prospectively assessed HRQoL in 128 patients with 
      catheterisation-confirmed PAH at baseline and at 6, 12 and post-24 month 
      follow-up visits. Cardiac-specific HRQoL was assessed using the Minnesota Living 
      with Heart Failure Questionnaire (LHFQ); respiratory-specific HRQoL was assessed 
      using the Airways Questionnaire 20 (AQ20); and general health status was assessed 
      using the 36-item Short Form physical component summary (SF-36 PCS). The LHFQ and 
      AQ20 were highly intercorrelated. Both demonstrated strong internal consistency 
      and converged with the SF-36 PCS. Both discriminated patients based on World 
      Health Organization (WHO) functional class, 6-min walking distance (6MWD) and 
      Borg dyspnoea index (BDI), with the exception of a potential floor effect 
      associated with low 6MWD. The LHFQ was more responsive than the AQ20 to changes 
      over time in WHO functional class, 6MWD and BDI. In multivariate analyses, the 
      LHFQ and AQ20 were each longitudinal predictors of general health status, 
      independent of functional class, 6MWD and BDI. In conclusion, both 
      cardiac-specific and respiratory-specific measures appropriately assess HRQoL in 
      most patients with PAH. Overall, the LHFQ demonstrates stronger performance 
      characteristics than the AQ20.
FAU - Chen, H
AU  - Chen H
AD  - Dept of Medicine, University of California, San Francisco, CA 94143-0924, USA. 
      hubert.chen@ucsf.edu
FAU - De Marco, T
AU  - De Marco T
FAU - Kobashigawa, E A
AU  - Kobashigawa EA
FAU - Katz, P P
AU  - Katz PP
FAU - Chang, V W
AU  - Chang VW
FAU - Blanc, P D
AU  - Blanc PD
LA  - eng
GR  - K23 HL086585-04/HL/NHLBI NIH HHS/United States
GR  - K23 HL086585-02/HL/NHLBI NIH HHS/United States
GR  - K23 HL086585/HL/NHLBI NIH HHS/United States
GR  - K23 HL086585-01A1/HL/NHLBI NIH HHS/United States
GR  - K23 HL086585-05/HL/NHLBI NIH HHS/United States
GR  - K23 HL086585-03/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110127
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CIN - Eur Respir J. 2011 Sep;38(3):512-3. PMID: 21885415
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Follow-Up Studies
MH  - Health Status
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension
MH  - Hypertension, Pulmonary/*diagnosis/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Quality of Life
MH  - Respiration
MH  - Surveys and Questionnaires
PMC - PMC3158810
MID - NIHMS292384
EDAT- 2011/01/29 06:00
MHDA- 2012/01/25 06:00
PMCR- 2012/09/01
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 09031936.00161410 [pii]
AID - 10.1183/09031936.00161410 [doi]
PST - ppublish
SO  - Eur Respir J. 2011 Sep;38(3):608-16. doi: 10.1183/09031936.00161410. Epub 2011 
      Jan 27.