PMID- 21273397
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20211020
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 173
IP  - 5
DP  - 2011 Mar 1
TI  - Questionnaire predictors of atopy in a US population sample: findings from the 
      National Health and Nutrition Examination Survey, 2005-2006.
PG  - 544-52
LID - 10.1093/aje/kwq392 [doi]
AB  - Allergic conditions and biochemical measures are both used to characterize atopy. 
      To assess questionnaires' ability to predict biochemical measures of atopy, the 
      authors used data on 5 allergic conditions (allergy, hay fever, eczema, rhinitis, 
      and itchy rash) and serum-specific immunoglobulin E (IgE) levels from the 
      2005-2006 National Health and Nutrition Examination Survey. Atopy was defined as 
      1 or more positive specific IgEs (>/=0.35 kU/L). Questionnaire responses were 
      assessed for sensitivity, specificity, and positive and negative predictive 
      values for atopy. In this population-based US sample, 44% of participants were 
      specific IgE-positive and 53% reported at least 1 allergic condition. Discordance 
      between atopy and allergic conditions was considerable; 37% of persons with atopy 
      reported no allergic condition, and 48% of persons who reported an allergic 
      condition were not atopic. Thus, no combination of self-reported allergic 
      conditions achieved both high sensitivity and high specificity for IgE. The 
      positive predictive value of reported allergic conditions for atopy ranged from 
      50% for eczema to 72% for hay fever, while the negative predictive value ranged 
      from 57% for eczema to 65% for any condition. Given the high proportion of 
      asymptomatic participants who were specific IgE-positive and persons who reported 
      allergic conditions but were specific IgE-negative, it is unlikely that 
      questionnaires will ever capture the same participants as those found to be 
      atopic by biochemical measures.
FAU - Hoppin, Jane A
AU  - Hoppin JA
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, 
      National Institutes of Health, Research Triangle Park, North Carolina 27709-2233, 
      USA. hoppin1@niehs.nih.gov
FAU - Jaramillo, Renee
AU  - Jaramillo R
FAU - Salo, Paivi
AU  - Salo P
FAU - Sandler, Dale P
AU  - Sandler DP
FAU - London, Stephanie J
AU  - London SJ
FAU - Zeldin, Darryl C
AU  - Zeldin DC
LA  - eng
GR  - Z01 ES025041/ImNIH/Intramural NIH HHS/United States
GR  - Z01ES025041/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20110127
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Biomarkers)
RN  - 0 (Immunologic Factors)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Child
MH  - Child, Preschool
MH  - Eczema/*epidemiology/immunology
MH  - Female
MH  - Health Surveys/*statistics & numerical data
MH  - Humans
MH  - Hypersensitivity/*epidemiology/immunology
MH  - Hypersensitivity, Immediate/epidemiology
MH  - Immunoglobulin E/*blood
MH  - Immunologic Factors/*blood
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys/statistics & numerical data
MH  - Predictive Value of Tests
MH  - Rhinitis, Allergic, Seasonal/epidemiology
MH  - Sampling Studies
MH  - Sensitivity and Specificity
MH  - Surveys and Questionnaires
MH  - United States/epidemiology
PMC - PMC3105435
EDAT- 2011/01/29 06:00
MHDA- 2011/04/19 06:00
PMCR- 2012/03/01
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - kwq392 [pii]
AID - 10.1093/aje/kwq392 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2011 Mar 1;173(5):544-52. doi: 10.1093/aje/kwq392. Epub 2011 Jan 
      27.