PMID- 21274402
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20220317
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Print)
IS  - 1110-7243 (Linking)
VI  - 2011
DP  - 2011
TI  - Contributions of cytogenetics and molecular cytogenetics to the diagnosis of 
      adipocytic tumors.
PG  - 524067
LID - 10.1155/2011/524067 [doi]
LID - 524067
AB  - Over the last 20 years, a number of tumor-specific chromosomal translocations and 
      associated fusion genes have been identified for mesenchymal neoplasms including 
      adipocytic tumors. The addition of molecular cytogenetic techniques, especially 
      fluorescence in situ hybridization (FISH), has further enhanced the sensitivity 
      and accuracy of detecting nonrandom chromosomal translocations and/or other 
      rearrangements in adipocytic tumors. Indeed, most resent molecular cytogenetic 
      analysis has demonstrated a translocation t(11;16)(q13;p13) that produces a 
      C11orf95-MKL2 fusion gene in chondroid lipoma. Additionally, it is well 
      recognized that supernumerary ring and/or giant rod chromosomes are 
      characteristic for atypical lipomatous tumor/well-differentiated liposarcoma and 
      dedifferentiated liposarcoma, and amplification of 12q13-15 involving the MDM2, 
      CDK4, and CPM genes is shown by FISH in these tumors. Moreover, myxoid/round cell 
      liposarcoma is characterized by a translocation t(12;16)(q13;p11) that fuses the 
      DDIT3 and FUS genes. This paper provides an overview of the role of conventional 
      cytogenetics and molecular cytogenetics in the diagnosis of adipocytic tumors.
FAU - Nishio, Jun
AU  - Nishio J
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 
      7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. jnishio@cis.fukuoka-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110111
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
SB  - IM
MH  - *Cytogenetic Analysis
MH  - Humans
MH  - Neoplasms, Adipose Tissue/*diagnosis/genetics/metabolism
PMC - PMC3025394
EDAT- 2011/01/29 06:00
MHDA- 2011/06/01 06:00
PMCR- 2011/01/11
CRDT- 2011/01/29 06:00
PHST- 2010/09/05 00:00 [received]
PHST- 2010/12/15 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PHST- 2011/01/11 00:00 [pmc-release]
AID - 10.1155/2011/524067 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2011;2011:524067. doi: 10.1155/2011/524067. Epub 2011 Jan 
      11.