PMID- 21274863
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20211020
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 53
IP  - 2
DP  - 2011 Feb
TI  - Strong influence of human leukocyte antigen (HLA)-DP gene variants on development 
      of persistent chronic hepatitis B virus carriers in the Han Chinese population.
PG  - 422-8
LID - 10.1002/hep.24048 [doi]
AB  - Chronic hepatitis B virus (HBV) infection is a major health issue, especially in 
      Asia. A recent genome-wide association study (GWAS) implicated genetic variants 
      in the human leukocyte antigen (HLA)-DP locus associated with chronic hepatitis B 
      in Japanese and Thai populations. To confirm whether the polymorphisms at the 
      HLA-DP genes are associated with persistent chronic HBV infection in Han Chinese, 
      we conducted an independent case-control study using 521 persistent chronic HBV 
      carriers and 819 controls that included 571 persons with HBV natural clearance 
      and 248 never HBV-infected (healthy) individuals. Eleven single nucleotide 
      polymorphisms (SNPs) in a region including HLA-DPA and HLA-DPB and an adjacent 
      SNP in strong linkage disequilibrium (LD) with a neighboring HLA-DR13 locus were 
      genotyped using the TaqMan SNP genotyping assay. Eleven variants at HLA-DP showed 
      a strong association with persistent chronic HBV carrier status (P = 1.82 x 
      10(-12) to 0.01). We also stratified the analysis by HBV clearance status to test 
      the association between these polymorphisms and HBV natural clearance; similar 
      results were obtained (P = 2.70 x 10(-11) to 0.003). Included SNPs define highly 
      structured haplotypes that were also strongly associated with HBV chronic 
      infection (block 1: odds ratio [OR] = 0.54, P = 8.73 x 10(-7) ; block 2: OR = 
      1.98, P = 1.37 x 10(-10) ). These results further confirm that genetic variants 
      in the HLA-DP locus are strongly associated with persistent HBV infection in the 
      Han Chinese population.
CI  - Copyright (c) 2010 American Association for the Study of Liver Diseases.
FAU - Guo, Xiuchan
AU  - Guo X
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory 
      Medicine and Life Science, Wenzhou Medical College, Zhejiang, China. 
      xguo1@cdc.gov
FAU - Zhang, Yong
AU  - Zhang Y
FAU - Li, Ji
AU  - Li J
FAU - Ma, Jingchen
AU  - Ma J
FAU - Wei, Zuli
AU  - Wei Z
FAU - Tan, Wenjie
AU  - Tan W
FAU - O'Brien, Stephen J
AU  - O'Brien SJ
LA  - eng
GR  - Z01 BC010317-09/ImNIH/Intramural NIH HHS/United States
GR  - N01 CO012400/CO/NCI NIH HHS/United States
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - Z01 BC010317-10/ImNIH/Intramural NIH HHS/United States
GR  - N01-CO-12400/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20110104
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPA antigen)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR13 antigen)
SB  - IM
CIN - Hepatology. 2011 Jul;54(1):375; author reply 375-6. PMID: 21563201
MH  - Adult
MH  - Carrier State/*virology
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Genetic Predisposition to Disease/ethnology/genetics
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP alpha-Chains
MH  - HLA-DP beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - Haplotypes/genetics
MH  - *Hepatitis B virus
MH  - Hepatitis B, Chronic/epidemiology/*ethnology/*genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
PMC - PMC3056070
MID - NIHMS245076
EDAT- 2011/01/29 06:00
MHDA- 2011/03/19 06:00
PMCR- 2012/02/01
CRDT- 2011/01/29 06:00
PHST- 2010/05/03 00:00 [received]
PHST- 2010/07/10 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - 10.1002/hep.24048 [doi]
PST - ppublish
SO  - Hepatology. 2011 Feb;53(2):422-8. doi: 10.1002/hep.24048. Epub 2011 Jan 4.