PMID- 21275795
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20131121
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 33
IP  - 3
DP  - 2011 Sep
TI  - Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from 
      kimchi in mice.
PG  - 539-44
LID - 10.3109/08923973.2010.549136 [doi]
AB  - To isolate antipruritic lactic acid bacteria (LAB) from kimchi, a traditional 
      Korean food, we investigated the interleukin (IL)-4 production-inhibitory effect 
      in the colon of mice for previously isolated LAB. Orally administered 
      Lactobacillus plantarum PM008 potently inhibited the expression of IgE-switching 
      cytokine, IL-4, and of proinflammatory cytokines, IL-1beta and TNF-alpha, in the colon 
      of mice. Its inhibitory effect was dependent on the dosage and administration 
      period. When PM008 was orally administered to mice, the number of PM008 detected 
      in the intestine and feces by polymerase chain reaction (PCR) and fluorescence in 
      situ hybridization (FISH) methods was dependent on the administration dosage and 
      period. The number of PM008 attached in the intestine was gradually decreased 
      with increasing time after completion of its oral administration. PM008 
      dose-dependently inhibited the scratching behavior induced by histamine or 
      compound 48/80. PM008 treated at a dose of 1 x 10(10) CFU for 14 days inhibited 
      the histamine- and compound 48/80-induced scratching behaviors by 32.8% and 
      48.6%, respectively. This inhibitory effect continued, although reduced, at 7 
      days after stopping the oral administration of PM008 attached in the intestine. 
      Based on these findings, L. plantarum PM008 may improve pruritus by inhibiting 
      IL-4 expression.
FAU - Jang, Se-Eun
AU  - Jang SE
AD  - Department of Food and Nutrition, Kyung Hee University, Dongdaemun-ku, Seoul, 
      Korea.
FAU - Hyun, Yang-Jin
AU  - Hyun YJ
FAU - Trinh, Hien-Trung
AU  - Trinh HT
FAU - Han, Myung Joo
AU  - Han MJ
FAU - Kim, Dong-Hyun
AU  - Kim DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110129
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Antipruritics)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Antipruritics/*pharmacology
MH  - Colon/immunology/metabolism/microbiology
MH  - Feces/microbiology
MH  - Histamine/pharmacology
MH  - Interleukin-1beta/antagonists & inhibitors
MH  - Interleukin-4/antagonists & inhibitors/biosynthesis
MH  - *Lactobacillus plantarum/isolation & purification
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Probiotics/isolation & purification/*pharmacology
MH  - Pruritus/chemically induced/*drug therapy
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2011/02/01 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 10.3109/08923973.2010.549136 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2011 Sep;33(3):539-44. doi: 
      10.3109/08923973.2010.549136. Epub 2011 Jan 29.