PMID- 21279392
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20211020
IS  - 1432-0932 (Electronic)
IS  - 0940-6719 (Print)
IS  - 0940-6719 (Linking)
VI  - 20
IP  - 8
DP  - 2011 Aug
TI  - Long-term reduction in pain and disability after surgery with the interspinous 
      device for intervertebral assisted motion (DIAM) spinal stabilization system in 
      patients with low back pain: 4-year follow-up from a longitudinal prospective 
      case series.
PG  - 1304-11
LID - 10.1007/s00586-011-1697-6 [doi]
AB  - Patients with low back pain (LBP) suffer chronic disability. In 40% of LBP 
      patients degenerative disc disease (DDD) seems to be the cause. This prospective 
      case series assessed the efficacy of the interspinous device for intervertebral 
      assisted motion (DIAM) in patients with LBP resulting from DDD. All patients 
      were initially assessed by physical examinations, magnetic resonance imaging, 
      dynamic X-rays and provocative discography. Eligible patients (n = 52) had LBP 
      for a minimum of 4 months, and received surgery with the DIAM system 2-4 weeks 
      after diagnosis. Patients were evaluated pre-/post-operatively for pain severity 
      using a visual analogue scale (VAS), and for dysfunction and disability with the 
      Roland-Morris Disability Questionnaire (RMDQ). VAS and RMDQ score changes were 
      assessed using the appropriate contrasts and Bonferroni-corrected P values. As a 
      result, significant (P < 0.0001) pain score reductions were observed between 
      baseline values, and 2 (3.7, 95% CI 3.1; 4.2) and 48 (3.1, 95% CI 2.5; 3.6) 
      months follow-up (intent-to-treat population). Disability scores were 
      significantly (P < 0.0001) reduced between baseline and 2 (8.6, 95% CI 7.4; 9.9) 
      and 48 (7.5, 95% CI 6.1; 8.9) months. Disability scores were similar from months 
      2 to 48. At 48 months, 67.3% of patients reached the minimum clinically important 
      difference (MCID; >/=1.5-unit improvement) in VAS score and 78.9% of patients 
      reached the MCID (>/=30% improvement) in RMDQ score. No complications were 
      associated with surgery. In conclusion, patients with LBP treated with the 
      interspinous DIAM system showed significant and clinically meaningful 
      improvements in pain and disability for up to 4 years.
FAU - Buric, Josip
AU  - Buric J
AD  - Unita Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy. 
      joburic@tin.it
FAU - Pulidori, Massimiliano
AU  - Pulidori M
LA  - eng
PT  - Journal Article
DEP - 20110129
PL  - Germany
TA  - Eur Spine J
JT  - European spine journal : official publication of the European Spine Society, the 
      European Spinal Deformity Society, and the European Section of the Cervical Spine 
      Research Society
JID - 9301980
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Internal Fixators/standards
MH  - Intervertebral Disc Degeneration/pathology/physiopathology/surgery
MH  - Joint Instability/pathology/physiopathology/*surgery
MH  - Longitudinal Studies
MH  - Low Back Pain/pathology/physiopathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Spinal Fusion/*instrumentation/methods
MH  - Spondylosis/pathology/physiopathology/*surgery
PMC - PMC3175853
EDAT- 2011/02/01 06:00
MHDA- 2012/06/01 06:00
PMCR- 2012/08/01
CRDT- 2011/02/01 06:00
PHST- 2010/07/30 00:00 [received]
PHST- 2011/01/09 00:00 [accepted]
PHST- 2010/11/23 00:00 [revised]
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 1697 [pii]
AID - 10.1007/s00586-011-1697-6 [doi]
PST - ppublish
SO  - Eur Spine J. 2011 Aug;20(8):1304-11. doi: 10.1007/s00586-011-1697-6. Epub 2011 
      Jan 29.