PMID- 21279501
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20211020
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Print)
IS  - 0946-2716 (Linking)
VI  - 89
IP  - 6
DP  - 2011 Jun
TI  - Is CaMKII a link between inflammation and hypertrophy in heart?
PG  - 537-43
LID - 10.1007/s00109-011-0727-5 [doi]
AB  - Myocardial infarction is a major cause of morbidity and mortality in the 
      developing and developed world. Although current interventions have been 
      successful in prolonging life, they are inadequate because mortality is still 
      high among MI patients. The multifunctional Ca(2+)/calmodulin-dependent protein 
      kinase (CaMKII) plays a key role in the structure and contractility of the 
      myocardium. CaMKII activity is increased in MI hearts and CaMKII promotes cardiac 
      hypertrophy and inflammation, processes consistently activated by myocardial 
      injury. Hypertrophy and inflammation are also related to neurohumoral and redox 
      signaling which uncouple CaMKII activation from Ca(2+)/calmodulin dependence. 
      Thus, CaMKII may act as a nodal point for integrating hypertrophic and 
      inflammatory signaling in myocardium.
FAU - Singh, Madhu V
AU  - Singh MV
AD  - Department of Internal Medicine, Carver College of Medicine, University of Iowa, 
      Iowa City, 52242, USA. madhu-singh@uiowa.edu
FAU - Anderson, Mark E
AU  - Anderson ME
LA  - eng
GR  - R01 HL079031/HL/NHLBI NIH HHS/United States
GR  - HL-079031/HL/NHLBI NIH HHS/United States
GR  - R01 HL070250/HL/NHLBI NIH HHS/United States
GR  - 1R01 HL070250/HL/NHLBI NIH HHS/United States
GR  - R01 HL096652/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110129
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (NF-kappa B)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Toll-Like Receptors)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
MH  - Cardiomegaly/metabolism/pathology/*physiopathology
MH  - Heart/physiopathology
MH  - Humans
MH  - Inflammation/*physiopathology
MH  - Mice
MH  - Myocardial Infarction/physiopathology
MH  - Myocardium/metabolism
MH  - NF-kappa B/metabolism
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
MH  - Toll-Like Receptors/metabolism
PMC - PMC3731449
MID - NIHMS498535
EDAT- 2011/02/01 06:00
MHDA- 2011/09/20 06:00
PMCR- 2013/08/01
CRDT- 2011/02/01 06:00
PHST- 2010/11/14 00:00 [received]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2010/12/09 00:00 [revised]
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - 10.1007/s00109-011-0727-5 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2011 Jun;89(6):537-43. doi: 10.1007/s00109-011-0727-5. Epub 
      2011 Jan 29.