PMID- 21281059
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20120105
IS  - 1473-7760 (Electronic)
IS  - 1052-0295 (Linking)
VI  - 87
IP  - 2
DP  - 2012 Feb
TI  - Age-related changes in apoptosis in rat hippocampus induced by oxidative stress.
PG  - 98-104
LID - 10.3109/10520295.2011.556665 [doi]
AB  - Also known as programmed cell death, apoptosis is a sequence of events that leads 
      to elimination of cells without releasing harmful substances into the surrounding 
      area. Apoptosis may be induced by intracellular or extracellular signals. Certain 
      apoptotic signals activate mitochondrial pro-apoptotic events and increase 
      reactive oxygen species (ROS). Increased ROS production may lead to oxidative 
      stress. The goal of our study was to characterize age-related changes in 
      apoptosis induced by oxidative stress in the hippocampus. Rats 2, 7, 21 and 38 
      days old, and adult rats were used for our study. Hippocampal CA1, CA2, CA3 and 
      dentate gyrus apoptosis, and hippocampal superoxide dismutase (SOD), glutathione 
      peroxidase (GPx) enzyme activities and thiobarbituric acid reactive substances 
      (TBARS) levels were measured. We found that numbers of hippocampal neurons were 
      low in rats 2, 7 and 21 days old (CA1, p < 0.001; CA3, p < 0.05; gyrus dentatus, 
      p < 0.001). The terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL) positive cell count was highest in the CA1 and dentate gyrus of 
      21-day-old rats. Among 21-day-old rats, the hippocampal TBARS levels and SOD 
      enzyme activity were high, whereas GPx activity was low. These results 
      demonstrate that the hippocampal CA1 and dentate gyrus of 21-day-old rats are 
      more prone to damage by oxidative stress.
FAU - Uysal, N
AU  - Uysal N
AD  - Dokuz Eylul University, School of Medicine, Department of Physiology, Izmir, 
      Turkey. nazan.uysal@deu.edu.tr
FAU - Tugyan, K
AU  - Tugyan K
FAU - Aksu, I
AU  - Aksu I
FAU - Ozbal, S
AU  - Ozbal S
FAU - Ozdemir, D
AU  - Ozdemir D
FAU - Dayi, A
AU  - Dayi A
FAU - Gonenc, S
AU  - Gonenc S
FAU - Acikgoz, O
AU  - Acikgoz O
LA  - eng
PT  - Journal Article
DEP - 20110131
PL  - England
TA  - Biotech Histochem
JT  - Biotechnic & histochemistry : official publication of the Biological Stain 
      Commission
JID - 9107378
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Dentate Gyrus/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Hippocampus/*cytology/growth & development/*metabolism
MH  - Lipid Peroxidation/*physiology
MH  - Male
MH  - Neurons/metabolism
MH  - Oxidative Stress/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Superoxide Dismutase/metabolism
EDAT- 2011/02/02 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 10.3109/10520295.2011.556665 [doi]
PST - ppublish
SO  - Biotech Histochem. 2012 Feb;87(2):98-104. doi: 10.3109/10520295.2011.556665. Epub 
      2011 Jan 31.