PMID- 21281237
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20221207
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 52
IP  - 2
DP  - 2011 Feb
TI  - Intermediate prognosis of 6q deletion in chronic lymphocytic leukemia.
PG  - 230-7
LID - 10.3109/10428194.2010.542599 [doi]
AB  - Cytogenetic features have an important role in the definition of distinct disease 
      subsets in CLL. The deletion of 6q is known to occur at a relatively low 
      frequency in CLL, and the detailed analysis of hematologic and clinical features 
      of patients with CLL with 6q deletion is limited. To verify the incidence and 
      prognostic significance of 6q deletion in Chinese patients with CLL, fluorescence 
      in situ hybridization (FISH) was used in 240 patients with CLL. del(6q23) was 
      found in 18 patients (7.5%), and only five patients had deletion in 6q23 as the 
      sole abnormality. Strong correlations between del(6q23) and clinical parameters 
      were not found. A difference in terms of survival in patients with del(6q23) as 
      compared with patients without this anomaly was not able to be demonstrated. 
      However, a significant difference was found when comparing the del(6q23) group 
      with the del(17p13) or del(11q22.3) group (p = 0.023), or isolated del(13q14) 
      group (p = 0.019). Our findings place the del(6q23) cytogenetic subset of CLL in 
      an intermediate prognosis position between patients with del(11q22.3) or 
      del(17p13), and patients with isolated del(13q14). FISH probes to detect 
      deletions of 6q might be useful in clinical practice in the work-up of patients 
      with CLL.
FAU - Wang, Dong-Mei
AU  - Wang DM
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing, China.
FAU - Miao, Kou-Rong
AU  - Miao KR
FAU - Fan, Lei
AU  - Fan L
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Fang, Cheng
AU  - Fang C
FAU - Zhu, Dan-Xia
AU  - Zhu DX
FAU - Qiu, Hong-Xia
AU  - Qiu HX
FAU - Xu, Wei
AU  - Xu W
FAU - Li, Jian-Yong
AU  - Li JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Biomarkers, Tumor/*genetics
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Survival Rate
EDAT- 2011/02/02 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.3109/10428194.2010.542599 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2011 Feb;52(2):230-7. doi: 10.3109/10428194.2010.542599.