PMID- 21281818
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20211020
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 178
IP  - 2
DP  - 2011 Feb
TI  - Gene expression patterns related to vascular invasion and aggressive features in 
      endometrial cancer.
PG  - 861-71
LID - 10.1016/j.ajpath.2010.10.040 [doi]
AB  - The presence of tumor cells entering vascular channels is a prognostic marker for 
      many cancers, including endometrial carcinoma. Vascular invasion is considered to 
      be an early step in the metastatic process and important for the progress of 
      malignant tumors. Here, we investigated the gene expression patterns related to 
      vascular involvement in 57 primary endometrial cancers, using DNA microarray and 
      quantitative PCR techniques. A vascular invasion signature of 18 genes was 
      significantly associated with patient survival and clinicopathological phenotype. 
      Vascular involvement was also related to gene sets for epithelial-mesenchymal 
      transition, wound response, endothelial cells, and vascular endothelial growth 
      factor (VEGF) activity. With immunohistochemical validation, both collagen 8 and 
      matrix metalloproteinase 3 (MMP3) were associated with vascular invasion, whereas 
      ANGPTL4 and IL-8 were associated with patient survival. Our findings indicate 
      that vascular involvement within primary tumors is associated with gene 
      expression profiles related to angiogenesis and epithelial-mesenchymal 
      transition. These data could contribute to an improved understanding of potential 
      targets for metastatic spread and may provide clinically important information 
      for better management of endometrial cancer.
CI  - Copyright (c) 2011 American Society for Investigative Pathology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Mannelqvist, Monica
AU  - Mannelqvist M
AD  - Section for Pathology, The Gade Institute, University of Bergen, Bergen, Norway.
FAU - Stefansson, Ingunn M
AU  - Stefansson IM
FAU - Bredholt, Geir
AU  - Bredholt G
FAU - Hellem Bo, Trond
AU  - Hellem Bo T
FAU - Oyan, Anne M
AU  - Oyan AM
FAU - Jonassen, Inge
AU  - Jonassen I
FAU - Kalland, Karl-Henning
AU  - Kalland KH
FAU - Salvesen, Helga B
AU  - Salvesen HB
FAU - Akslen, Lars A
AU  - Akslen LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Blotting, Western
MH  - Cluster Analysis
MH  - Endometrial Neoplasms/*genetics/*pathology
MH  - Endothelial Cells/metabolism/pathology
MH  - Female
MH  - *Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neovascularization, Pathologic/*genetics
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Reproducibility of Results
MH  - Survival Analysis
PMC - PMC3070569
EDAT- 2011/02/02 06:00
MHDA- 2011/05/24 06:00
PMCR- 2012/02/01
CRDT- 2011/02/02 06:00
PHST- 2010/07/02 00:00 [received]
PHST- 2010/08/31 00:00 [revised]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - S0002-9440(10)00136-7 [pii]
AID - AJPA135 [pii]
AID - 10.1016/j.ajpath.2010.10.040 [doi]
PST - ppublish
SO  - Am J Pathol. 2011 Feb;178(2):861-71. doi: 10.1016/j.ajpath.2010.10.040.