PMID- 21282274
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20240402
IS  - 1938-2731 (Electronic)
IS  - 1533-3175 (Print)
IS  - 1533-3175 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Feb
TI  - Risk of cerebrovascular adverse events and death in elderly patients with 
      dementia when treated with antipsychotic medications: a literature review of 
      evidence.
PG  - 10-28
LID - 10.1177/1533317510390351 [doi]
AB  - Behavioral and Psychological Symptoms of Dementia (BPSD) are increasingly 
      recognized as a major risk factor for caregiver burden, institutionalization, 
      greater impairment in activities of daily living (ADLs), more rapid cognitive 
      decline, and a poorer quality of life. BPSD contribute significantly to the 
      direct and indirect costs of caring for patients with dementia even after 
      adjusting for the severity of cognitive impairment and other co-morbidities. 
      Research on these symptoms has indicated a complex interplay between the 
      biological, psychological and social factors involved in the disease process. 
      Although some psychotropic medications have shown modest efficacy in the 
      treatment of these behaviors, their use has generated controversy due to 
      increasing recognition of the side effects of these medications especially the 
      antipsychotic medications. In this review, we examine the risk of cerebrovascular 
      adverse events (CVAEs) and death with antipsychotic medications when used to 
      treat elderly patients with dementia.
FAU - Mittal, Vikrant
AU  - Mittal V
AD  - BJC Healthcare System, Farmington, MO, USA.
FAU - Kurup, Lekshminarayana
AU  - Kurup L
FAU - Williamson, Deena
AU  - Williamson D
FAU - Muralee, Sunanda
AU  - Muralee S
FAU - Tampi, Rajesh R
AU  - Tampi RR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Alzheimers Dis Other Demen
JT  - American journal of Alzheimer's disease and other dementias
JID - 101082834
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antipsychotic Agents/*adverse effects/therapeutic use
MH  - Dementia/complications/*drug therapy
MH  - Humans
MH  - Risk Factors
MH  - Stroke/*chemically induced/mortality
PMC - PMC10845396
EDAT- 2011/02/02 06:00
MHDA- 2011/05/25 06:00
PMCR- 2011/02/01
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - 26/1/10 [pii]
AID - 10.1177_1533317510390351 [pii]
AID - 10.1177/1533317510390351 [doi]
PST - ppublish
SO  - Am J Alzheimers Dis Other Demen. 2011 Feb;26(1):10-28. doi: 
      10.1177/1533317510390351.