PMID- 21282995
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110609
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 30
IP  - 7
DP  - 2011 Jul
TI  - Relation between total tear IgE and specific serum IgE in seasonal allergic 
      conjunctivitis.
PG  - 790-5
LID - 10.1097/ICO.0b013e3182000feb [doi]
AB  - PURPOSE: Recently, a new commercial test for total tear immunoglobulin E (IgE), 
      based on immunochromatography (Allerwatch), was developed. We examined the 
      relation between the total IgE level in tears and specific serum IgE. METHODS: A 
      prospective, nonrandomized, cross-sectional study was conducted in 35 patients 
      with allergic conjunctivitis (allergic group), 30 age- and sex-matched healthy 
      control subjects (control group), and 8 patients with epidemic 
      keratoconjunctivitis. In all subjects, the total tear IgE score was determined 
      with the Allerwatch test (0, 1, and 2), and serum levels of total IgE and 
      specific IgE for 12 inhaled allergens were measured with the Phadezym PRIST and 
      CAP-RAST systems, respectively. RESULTS: The total tear IgE-positive rate was 
      significantly higher in the allergic group than in the control and epidemic 
      keratoconjunctivitis groups (100.0% vs. 0.0% vs. 0.0%; P < 0.00001). In the 
      allergic group, the total tear IgE score was significantly correlated with the 
      log-transformed total serum IgE level (r = 0.61) and with the serum levels of IgE 
      for cedar pollen (r = 0.35), house dust (r = 0.46), Dermatophagoides 
      pteronyssinus (r = 0.49), and acarus (r = 0.36). Multivariate logistic regression 
      analysis showed that the log-transformed total serum IgE level was the only 
      significant predictor of the total tear IgE score (odds ratio = 1.85, P = 
      0.00008). CONCLUSIONS: The total tear IgE score, determined with the Allerwatch 
      test, was correlated with the total and specific serum IgE levels. This rapid 
      test is easy to perform, sensitive, and highly specific for the detection of 
      ocular allergy on an outpatient basis.
FAU - Mimura, Tatsuya
AU  - Mimura T
AD  - Department of Ophthalmology, Toranomon Hospital, Tokyo, Japan. 
      mimurat-tky@umin.ac.jp
FAU - Usui, Tomohiko
AU  - Usui T
FAU - Mori, Mikiro
AU  - Mori M
FAU - Funatsu, Hideharu
AU  - Funatsu H
FAU - Noma, Hidetaka
AU  - Noma H
FAU - Yamamoto, Hiroki
AU  - Yamamoto H
FAU - Aixinjueluo, Wei
AU  - Aixinjueluo W
FAU - Amano, Shiro
AU  - Amano S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Child
MH  - Conjunctivitis, Allergic/diagnosis/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Prospective Studies
MH  - Radioallergosorbent Test
MH  - Radioimmunoassay
MH  - Seasons
MH  - Sensitivity and Specificity
MH  - Tears/*immunology
MH  - Young Adult
EDAT- 2011/02/02 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1097/ICO.0b013e3182000feb [doi]
PST - ppublish
SO  - Cornea. 2011 Jul;30(7):790-5. doi: 10.1097/ICO.0b013e3182000feb.