PMID- 21283014
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20211020
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 57
IP  - 1
DP  - 2011 May 1
TI  - HLA alleles are associated with altered risk for disease progression and central 
      nervous system impairment of HIV-infected children.
PG  - 32-9
LID - 10.1097/QAI.0b013e3182119244 [doi]
AB  - OBJECTIVE: To examine the effects of human leukocyte antigen (HLA) alleles on 
      HIV-1-related disease progression and central nervous system (CNS) impairment in 
      children. DESIGN: Five hundred seventy-two HIV-1-infected children, identified as 
      disease progressors or nonprogressors, were selected from PACTG P152 and P300 
      through a case-cohort sampling scheme. Study endpoints were HIV-1-related disease 
      progression-free survival and time to CNS impairment. METHODS: DNA was genotyped 
      for HLA alleles using a Luminex 100 platform. Weighted Kaplan-Meier methods, and 
      Cox proportional hazards models were used to assess the effects of HLA alleles on 
      study endpoints. RESULTS: Presence of the B-27 allele (n = 20) was associated 
      with complete protection against disease progression and CNS impairment over the 
      median follow-up of 26 months (P < 0.0001 for both). These findings held in 
      multivariate analyses controlling for baseline covariates including race, gender, 
      age, log HIV-1 RNA, CD4 lymphocyte count and percent, weight for age z score and 
      treatment, and for other genotypes shown to affect HIV-1-related disease 
      progression. Also, although the Cw-2 allele protected against disease progression 
      [Hazard ratio (HR), 0.48; 95% confidence interval (CI): 0.28 to 0.81; P = 0.006], 
      the A-24 allele was associated with more rapid CNS impairment (HR: 2.01; 95% CI: 
      1.04 to 3.88; P = 0.04). The HLA class II DQB1-2 allele was associated with a 
      delayed disease progression (HR: 0.66; 95% CI: 0.47-0.92; P = 0.01) and CNS 
      impairment (HR: 0.58; 95% CI: 0.36 to 0.93; P = 0.02). CONCLUSIONS: Presence of 
      B-27, Cw-2, or DQB1-2 alleles was associated with delayed HIV-1 disease 
      progression, while B-27, A-24, and DQB1-2 alleles were associated with altered 
      progression to CNS impairment in children.
FAU - Singh, Kumud K
AU  - Singh KK
AD  - Department of Pediatrics, Division of Infectious Diseases, University of 
      California San Diego, La Jolla, CA 92093-0672, USA. kusingh@ucsd.edu
FAU - Gray, Ping Kathryn
AU  - Gray PK
FAU - Wang, Yan
AU  - Wang Y
FAU - Fenton, Terence
AU  - Fenton T
FAU - Trout, Rodney N
AU  - Trout RN
FAU - Spector, Stephen A
AU  - Spector SA
LA  - eng
GR  - AI-069536/AI/NIAID NIH HHS/United States
GR  - R01 MH085608-02/MH/NIMH NIH HHS/United States
GR  - 5R01MH085608/MH/NIMH NIH HHS/United States
GR  - R01 MH085608/MH/NIMH NIH HHS/United States
GR  - U01 AI069536/AI/NIAID NIH HHS/United States
GR  - UM1 AI069536/AI/NIAID NIH HHS/United States
GR  - R01 NS077874/NS/NINDS NIH HHS/United States
GR  - U01 AI068632-04S3/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (DNA, Viral)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - *Alleles
MH  - Case-Control Studies
MH  - Central Nervous System Diseases/genetics/immunology/pathology/*virology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - DNA, Viral/chemistry/genetics
MH  - Disease Progression
MH  - Female
MH  - Genotype
MH  - HIV Infections/*genetics/*immunology/pathology/virology
MH  - *HIV-1
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Infant
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Polymerase Chain Reaction
PMC - PMC3107908
MID - NIHMS272908
EDAT- 2011/02/02 06:00
MHDA- 2011/08/27 06:00
PMCR- 2011/07/22
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PHST- 2011/07/22 00:00 [pmc-release]
AID - 10.1097/QAI.0b013e3182119244 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2011 May 1;57(1):32-9. doi: 
      10.1097/QAI.0b013e3182119244.