PMID- 21284665
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20220330
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Linking)
VI  - 35
IP  - 5
DP  - 2011 May
TI  - Dendritic cells in alcoholic liver injury and fibrosis.
PG  - 776-81
LID - 10.1111/j.1530-0277.2010.01397.x [doi]
AB  - Alcohol consumption impairs the development of innate and adaptive immune 
      responses, however the exact mechanism by which alcohol leads to immune defects 
      remains to be established. Dendritic cells (DCs) form a heterogeneous population 
      of hematopoietic cells that are present in all tissues including the liver. DC 
      are initially described playing a key role in the induction of innate and 
      adaptive immune response against specific antigens. In our presentation, we 
      discussed few new aspects of DC development, critical assessment of DC in 
      non-lymphoid organs and the impact of alcohol consumption on DC function. 
      Understanding the mechanism by which DC modulate liver function after alcohol 
      consumption may help uncover novel therapeutic strategies for the treatment of 
      these conditions.
CI  - Copyright (c) 2011 by the Research Society on Alcoholism.
FAU - Aloman, Costica
AU  - Aloman C
AD  - Division of Liver Diseases, Department of Medicine, Mount Sinai School of 
      Medicine, New York, New York 10029, USA. costica.aloman@mssm.edu
FAU - Friedman, Scott L
AU  - Friedman SL
FAU - Merad, Miriam
AU  - Merad M
LA  - eng
GR  - K08 DK088954/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20110201
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
SB  - IM
MH  - Adaptive Immunity/immunology
MH  - Alcohol Drinking/adverse effects/*immunology
MH  - Alcoholism/complications/immunology
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Cellular/immunology
MH  - Liver Cirrhosis, Alcoholic/complications/*immunology
EDAT- 2011/02/03 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - 10.1111/j.1530-0277.2010.01397.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2011 May;35(5):776-81. doi: 
      10.1111/j.1530-0277.2010.01397.x. Epub 2011 Feb 1.