PMID- 21285386
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20220318
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 34
IP  - 3
DP  - 2011 Mar
TI  - Urine C-peptide creatinine ratio is a noninvasive alternative to the mixed-meal 
      tolerance test in children and adults with type 1 diabetes.
PG  - 607-9
LID - 10.2337/dc10-2114 [doi]
AB  - OBJECTIVE: Stimulated serum C-peptide (sCP) during a mixed-meal tolerance test 
      (MMTT) is the gold standard measure of endogenous insulin secretion, but 
      practical issues limit its use. We assessed urine C-peptide creatinine ratio 
      (UCPCR) as an alternative. RESEARCH DESIGN AND METHODS: Seventy-two type 1 
      diabetic patients (age of diagnosis median 14 years [interquartile range 10-22]; 
      diabetes duration 6.5 [2.3-32.7]) had an MMTT. sCP was collected at 90 min. Urine 
      for UCPCR was collected at 120 min and following a home evening meal. RESULTS: 
      MMTT 120-min UCPCR was highly correlated to 90-min sCP (r = 0.97; P < 0.0001). 
      UCPCR >/= 0.53 nmol/mmol had 94% sensitivity/100% specificity for significant 
      endogenous insulin secretion (90-min sCP >/= 0.2 nmol/L). The 120-min postprandial 
      evening meal UCPCR was highly correlated to 90-min sCP (r = 0.91; P < 0.0001). 
      UCPCR >/= 0.37 nmol/mmol had 84% sensitivity/97% specificity for sCP >/= 0.2 nmol/L. 
      CONCLUSIONS: UCPCR testing is a sensitive and specific method for detecting 
      insulin secretion. UCPCR may be a practical alternative to serum C-peptide 
      testing, avoiding the need for inpatient investigation.
FAU - Besser, Rachel E J
AU  - Besser RE
AD  - Peninsula National Institute for Health Research Clinical Research Facility, 
      Peninsula Medical School, University of Exeter, Exeter, UK.
FAU - Ludvigsson, Johnny
AU  - Ludvigsson J
FAU - Jones, Angus G
AU  - Jones AG
FAU - McDonald, Timothy J
AU  - McDonald TJ
FAU - Shields, Beverley M
AU  - Shields BM
FAU - Knight, Bridget A
AU  - Knight BA
FAU - Hattersley, Andrew T
AU  - Hattersley AT
LA  - eng
GR  - DRF-2010-03-72/DH_/Department of Health/United Kingdom
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110201
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (C-Peptide)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - C-Peptide/*urine
MH  - Creatinine/*urine
MH  - Diabetes Mellitus, Type 1/*urine
MH  - Female
MH  - Glucose Tolerance Test/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3041191
EDAT- 2011/02/03 06:00
MHDA- 2011/06/09 06:00
PMCR- 2012/03/01
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - dc10-2114 [pii]
AID - 2114 [pii]
AID - 10.2337/dc10-2114 [doi]
PST - ppublish
SO  - Diabetes Care. 2011 Mar;34(3):607-9. doi: 10.2337/dc10-2114. Epub 2011 Feb 1.