PMID- 21285738 OWN - NLM STAT- MEDLINE DCOM- 20110523 LR - 20220316 IS - 1558-2035 (Electronic) IS - 1558-2027 (Linking) VI - 12 IP - 3 DP - 2011 Mar TI - Predictors of exercise capacity in patients with chronic heart failure. PG - 223-5 LID - 10.2459/JCM.0b013e328343e950 [doi] AB - BACKGROUND: Heart failure is a major and growing societal problem characterized by high mortality, frequent hospitalization, reduced quality of life and a complex therapeutic regimen. The six-minute walking test (6-MWT) may serve as a useful and reproducible test for assessing exercise capacity in heart failure patients and has been suggested as a simple, well-tolerated and inexpensive alternative to cardiopulmonary exercise testing (CPET). The CPET and 6-MWT are the most broadly used for assessing functional limitation in patients with heart failure. Echocardiography is well qualified to meet the growing need for noninvasive imaging in the expanding heart failure population. METHODS: This study included 132 consecutive patients (61 +/- 10 years, 45% women) with stable heart failure. All patients underwent 6-MWT and Doppler echocardiographic examination on the same day. Clinical, biochemical and echocardiographic predictors were analyzed to assess predictors of exercise capacity. Patients were divided into two groups based on the 6-MWT distance. The first group comprised patients with limited exercise performance (300 m). RESULTS: In univariate analysis, patients' age [0.931 (0.895-0.968), P < 0.001], arterial hypertension [0.481 (0.239-0.967), P = 0.040], blood urea level [0.860 (0.759-0.975), P = 0.019], New York Heart Association (NYHA) class [0.441 (0.245-0.795), P = 0.006], early diastolic E wave [1.014 (1.000-1.029), P = 0.047], total isovolumic time (t-IVT) [0.868 (0.796-0.947), P = 0.001], Tei index [0.112 (0.028-0.450), P = 0.002], and E' of left-ventricular (LV) lateral wall [1.188 (1.099-1.400), P = 0.039] independently predicted poor 6-MWT performance (<300 m). In multivariate analysis, only patients' age [0.948 (0.902-0.996), P = 0.034], arterial hypertension [0.351 (0.133-0.922), P = 0.034], and t-IVT [0.828 (0.725-0.946), P = 0.005] independently predicted poor 6-MWT performance (<300 m). CONCLUSION: In chronic stable heart failure patients, in addition to age, systemic hypertension as well as LV asynchrony, as reflected by prolonged t-IVT, are independent predictors of poor exercise capacity. FAU - Daullxhiu, Irfan AU - Daullxhiu I AD - Cardiology Service, University Clinical Centre of Kosovo, Prishtina, Kosovo. irfan_daullxhiu@yahoo.com FAU - Haliti, Edmond AU - Haliti E FAU - Poniku, Afrim AU - Poniku A FAU - Ahmeti, Artan AU - Ahmeti A FAU - Hyseni, Violeta AU - Hyseni V FAU - Olloni, Rozafa AU - Olloni R FAU - Vela, Zana AU - Vela Z FAU - Elezi, Shpend AU - Elezi S FAU - Bajraktari, Gani AU - Bajraktari G FAU - Daullxhiu, Teuta AU - Daullxhiu T LA - eng PT - Journal Article PL - United States TA - J Cardiovasc Med (Hagerstown) JT - Journal of cardiovascular medicine (Hagerstown, Md.) JID - 101259752 SB - IM MH - Age Factors MH - Aged MH - Blood Pressure MH - Chi-Square Distribution MH - Chronic Disease MH - *Echocardiography, Doppler MH - *Exercise Test MH - *Exercise Tolerance MH - Female MH - Heart Failure/*diagnosis/diagnostic imaging/physiopathology MH - Humans MH - Linear Models MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Risk Assessment MH - Risk Factors MH - Stroke Volume MH - Time Factors MH - Ventricular Function, Left MH - *Walking EDAT- 2011/02/03 06:00 MHDA- 2011/05/24 06:00 CRDT- 2011/02/03 06:00 PHST- 2011/02/03 06:00 [entrez] PHST- 2011/02/03 06:00 [pubmed] PHST- 2011/05/24 06:00 [medline] AID - 01244665-201103000-00025 [pii] AID - 10.2459/JCM.0b013e328343e950 [doi] PST - ppublish SO - J Cardiovasc Med (Hagerstown). 2011 Mar;12(3):223-5. doi: 10.2459/JCM.0b013e328343e950.