PMID- 21286942
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20211020
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 116
IP  - 4
DP  - 2011 Jun
TI  - Screening of pancreaticoduodenal endocrine tumours in patients with MEN 1: 
      multidetector-row computed tomography vs. endoscopic ultrasound.
PG  - 595-606
LID - 10.1007/s11547-011-0636-2 [doi]
AB  - PURPOSE: The authors compared multidetector-row computed tomography (MDCT) and 
      endoscopic ultrasound (EUS) in the identification of pancreaticoduodenal 
      endocrine tumours (PETs) in patients with multiple endocrine neoplasia type 1 
      (MEN 1). MATERIALS AND METHODS: Fourteen consecutive patients (eight men and six 
      women, aged 26-54 years) with MEN 1 underwent MDCT performed with a 4- (n=5) or 
      64- (n=9) detector-row system and EUS done with a radial transducer (7.5-20 MHz) 
      within 7-28 days of each other. Prior to MDCT examination, patients were given 
      750 cc of water and asked to lie down in the right lateral decubitus for 15 min. 
      Multiphase MDCT images were acquired both before and after the injection of 
      nonionic iodinated contrast material (2 cc/kg) at an injection rate of 4 ml/s, 
      with technical parameters and scan delay varying in relation to the system used. 
      Images were all reconstructed at 3-mm intervals for the three phases (arterial, 
      pancreatic and portal) and evaluated on a dedicated workstation. RESULTS: MDCT 
      detected a total of 25 PETs (3-18 mm) in nine patients. Of these lesions, nine 
      were situated within the duodenal wall and 16 in either the pancreatic head 
      (n=3), body (n=7), or tail (n=6). Three additional lesions were detected 
      retrospectively after EUS imaging. Most (18/22, 81%) were hypervascular nodules, 
      and four appeared as either hypoattenuating or cystic lesions. EUS detected a 
      total of 32 PETs (2-18 mm) in 11 patients. Most lesions (29/32, 90%) appeared 
      hypoechoic and were situated in the duodenal wall (n=15) or in either the 
      pancreatic head (n=10), body (n=6) or tail (n=1). CONCLUSIONS: Our preliminary 
      data indicate that MDCT is complementary to EUS in the identification of PETs in 
      MEN-1 patients.
FAU - Camera, L
AU  - Camera L
AD  - Dipartimento di Scienze Bio-Morfologiche e Funzionali, Sez. di Diagnostica per 
      Immagini e Radioterapia (Ed. 10), Universita degli Studi di Napoli Federico II, 
      Via S. Pansini 5, 80131, Napoli, Italy. camera@unina.it
FAU - Paoletta, S
AU  - Paoletta S
FAU - Mollica, C
AU  - Mollica C
FAU - Milone, F
AU  - Milone F
FAU - Napolitano, V
AU  - Napolitano V
FAU - De Luca, L
AU  - De Luca L
FAU - Faggiano, A
AU  - Faggiano A
FAU - Colao, A
AU  - Colao A
FAU - Salvatore, M
AU  - Salvatore M
LA  - eng
LA  - ita
PT  - Comparative Study
PT  - Journal Article
DEP - 20110201
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Adult
MH  - Duodenal Neoplasms/*diagnostic imaging
MH  - Duodenum/diagnostic imaging
MH  - *Endosonography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging
MH  - Pancreas/diagnostic imaging
MH  - Pancreatic Neoplasms/*diagnostic imaging
MH  - *Tomography, X-Ray Computed
EDAT- 2011/02/03 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/02/03 06:00
PHST- 2010/04/01 00:00 [received]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 10.1007/s11547-011-0636-2 [doi]
PST - ppublish
SO  - Radiol Med. 2011 Jun;116(4):595-606. doi: 10.1007/s11547-011-0636-2. Epub 2011 
      Feb 1.