PMID- 21287528
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20151119
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 117
IP  - 15
DP  - 2011 Aug 1
TI  - Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor 
      patients after neurosurgery and radiotherapy: a preliminary report.
PG  - 3434-44
LID - 10.1002/cncr.25874 [doi]
AB  - BACKGROUND: Cognitive performance often is impaired permanently in long-term 
      brain tumor survivors after neurosurgery and radiotherapy. Hyperbaric oxygen 
      treatment (HBOT) stimulates neovascularization of hypoperfused tissue and may 
      result in improved functionality of damaged tissue. In this pilot study, clinical 
      neurophysiologic tests were used to assess the effect of HBOT on brain 
      performance. METHODS: Ten long-term brain tumor survivors received HBOT for 
      severe cognitive deficits after neurosurgery and radiosurgery. Patients were 
      tested before HBOT and at 6 weeks and 4 months after HBOT. The tests comprised a 
      quantitative electroencephalographic (EEG) examination, the Informant 
      Questionnaire on Cognitive Decline in the Elderly (IQCODE) for memory 
      performance, and 2 cognitive tests, the number connection test (NCT) and the 
      continuous reaction time test (CRTT). Late event-related components (LERCs) of 
      averaged evoked EEG responses to a visual odd-ball stimulus were analyzed from 
      whole-head activity maps. For comparison, a control group of healthy individuals 
      (no HBOT) also were investigated. RESULTS: After HBOT, the amplitude of the LERC 
      with the longest latency, P3b (involved in object interpretation) was improved 
      significantly (P = .02). The amplitudes of the N200 (occipital, negative) and the 
      intermediate P3a (centroparietal, positive), LERCs with shorter latencies, and of 
      a small, positive, occipital visual component did not change. Neither latencies 
      nor reaction times changed after HBOT. However, P3a and P3b (parietal, positive) 
      latencies were longer in survivors than in healthy individuals. The NCT produced 
      inconclusive results, but the IQCODE revealed an improvement. When outcomes of 
      the NCT, CRTT, IQCODE, and P3b amplitudes were evaluated in common tests, HBOT 
      appeared to provide substantial improvement (P<.006). CONCLUSIONS: On the basis 
      of the current results, the authors concluded tentatively that HBOT improves 
      neurophysiologic performance in long-term brain tumor survivors.
CI  - Copyright (c) 2011 American Cancer Society.
FAU - Schellart, Nico A M
AU  - Schellart NA
AD  - Biomedical Engineering and Physics, Academic Medical Center, University of 
      Amsterdam, Amsterdam, Netherlands. n.a.schellart@amc.nl
FAU - Reits, Dik
AU  - Reits D
FAU - van der Kleij, Adrian J
AU  - van der Kleij AJ
FAU - Stalpers, Lukas J A
AU  - Stalpers LJ
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/physiopathology/*radiotherapy/*surgery
MH  - Cognition
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
EDAT- 2011/02/03 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/02/03 06:00
PHST- 2010/09/03 00:00 [received]
PHST- 2010/11/09 00:00 [revised]
PHST- 2010/11/30 00:00 [accepted]
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1002/cncr.25874 [doi]
PST - ppublish
SO  - Cancer. 2011 Aug 1;117(15):3434-44. doi: 10.1002/cncr.25874. Epub 2011 Feb 1.