PMID- 21290392
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220331
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Mar
TI  - Phototherapy for chronic rhinosinusitis.
PG  - 187-91
LID - 10.1002/lsm.21042 [doi]
AB  - OBJECTIVES: Near-infrared laser illumination (NILI), with or without 
      photo-activated (PA) agents, has bactericidal and wound healing promoting 
      effects. NILI may have a potential role managing chronic rhinosinusitis (CRS). 
      METHODS: A prospective randomized study with 23 symptomatic post-surgical CRS 
      patients with positive cultures was conducted. Two groups (GR1 and GR2) were 
      treated with NILI. Objective nasal endoscopic scoring (NES) was elaborated. GR1 
      was treated with a 940 nm laser, while GR2 was treated with a topical PA agent, 
      indocyanine-green, followed with 810 nm laser. SNOT20 scores, NES, and cultures 
      were obtained prior to illumination. Saccharin test was performed 1 week 
      following treatment. RESULTS: Some cultures remained positive through treatment, 
      with Staph. aureus predominating. Both therapy arms demonstrated clinical 
      efficacy. The SNOT20 score change was 0.9, 0.8 for GR1 and GR2, respectively 
      (P < 0.05). Improvement (P < 0.05) was observed based on NES. No significant 
      difference was observed between two treatment groups. All passed the saccharin 
      test. Therapeutic effect was sustained for a minimum of 2 months. Side effects 
      were minimal. CONCLUSIONS: NILI was objectively and subjectively beneficial in 
      managing CRS, safe, reproducible, sustained and appeared not to interfere with 
      ciliary motility. CRS exacerbation was avoided without using antibiotics or 
      steroids.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Krespi, Yosef P
AU  - Krespi YP
AD  - St. Luke's-Roosevelt Hospital, New York, NewYork, USA. krespi@nyhni.org
FAU - Kizhner, Victor
AU  - Kizhner V
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110202
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
RN  - 0 (Photosensitizing Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Chronic Disease
MH  - Endoscopy
MH  - Female
MH  - Humans
MH  - Indocyanine Green/*therapeutic use
MH  - Lasers, Semiconductor/*therapeutic use
MH  - *Low-Level Light Therapy
MH  - Male
MH  - Middle Aged
MH  - *Photochemotherapy
MH  - Photosensitizing Agents/*therapeutic use
MH  - Prospective Studies
MH  - Quality of Life
MH  - Rhinitis/*drug therapy/microbiology/*radiotherapy
MH  - Severity of Illness Index
MH  - Sinusitis/*drug therapy/microbiology/*radiotherapy
MH  - Treatment Outcome
EDAT- 2011/02/04 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/02/04 06:00
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.1002/lsm.21042 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2011 Mar;43(3):187-91. doi: 10.1002/lsm.21042. Epub 2011 Feb 2.