PMID- 21291936
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20131121
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 32
IP  - 5
DP  - 2011 May
TI  - Effect of centrally administered apelin-13 on gastric emptying and 
      gastrointestinal transit in mice.
PG  - 978-82
LID - 10.1016/j.peptides.2011.01.023 [doi]
AB  - Apelin, as the endogenous ligand for the APJ, regulates many biological 
      functions, including blood pressure, neuroendocrine, drinking behavior, food 
      intake and colonic motility. The present study was designed to investigate the 
      effect of central apelin-13 on gastric emptying and gastrointestinal transit in 
      mice. Intracerebroventricular (i.c.v.) injection of apelin-13 (3 and 10 mug/mouse) 
      decreased gastric emptying rate by 10.9% and 17.1%. This effect was significantly 
      antagonized by the APJ receptor antagonist apelin-13(F13A) and the opioid 
      receptor antagonist naloxone, respectively. However, intraperitoneal (i.p.) 
      injection of apelin-13 (10-100 mug/mouse) did not affect gastric emptying. 
      Apelin-13 (0.3, 1 and 3 mug/mouse, i.c.v.) inhibited gastrointestinal transit by 
      16.8%, 23.4% and 19.2%. Apelin-13(F13A) and naloxone could also reverse this 
      antitransit effect induced by apelin-13. Taken together, these results suggest 
      that i.c.v. injected apelin-13 inhibits gastric emptying and gastrointestinal 
      transit and it seems that APJ receptor and opioid receptor might be involved in 
      these processes.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Lv, Shuang-Yu
AU  - Lv SY
AD  - Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou 
      University, 222 Tian Shui South Road, Lanzhou 730000, PR China.
FAU - Yang, Yan-Jie
AU  - Yang YJ
FAU - Qin, Yao-Jun
AU  - Qin YJ
FAU - Xiong, Wei
AU  - Xiong W
FAU - Chen, Qiang
AU  - Chen Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110201
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (apelin-13 peptide)
RN  - 36B82AMQ7N (Naloxone)
SB  - IM
MH  - Animals
MH  - Gastric Emptying/*drug effects
MH  - Gastrointestinal Transit/*drug effects
MH  - Injections, Intraventricular
MH  - Intercellular Signaling Peptides and Proteins/administration & 
      dosage/*pharmacology
MH  - Male
MH  - Mice
MH  - Naloxone/administration & dosage/pharmacology
EDAT- 2011/02/05 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/05 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/01/17 00:00 [revised]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0196-9781(11)00039-8 [pii]
AID - 10.1016/j.peptides.2011.01.023 [doi]
PST - ppublish
SO  - Peptides. 2011 May;32(5):978-82. doi: 10.1016/j.peptides.2011.01.023. Epub 2011 
      Feb 1.