PMID- 21292771
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20220330
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 117
IP  - 14
DP  - 2011 Apr 7
TI  - Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical 
      transplantation.
PG  - 3921-8
LID - 10.1182/blood-2010-10-311894 [doi]
AB  - Hastening posttransplantation immune reconstitution is a key challenge in human 
      leukocyte antigen (HLA)-haploidentical hematopoietic stem-cell transplantation 
      (HSCT). In experimental models of mismatched HSCT, T-regulatory cells (Tregs) 
      when co-infused with conventional T cells (Tcons) favored posttransplantation 
      immune reconstitution and prevented lethal graft-versus-host disease (GVHD). In 
      the present study, we evaluated the impact of early infusion of Tregs, followed 
      by Tcons, on GVHD prevention and immunologic reconstitution in 28 patients with 
      high-risk hematologic malignancies who underwent HLA-haploidentical HSCT. We show 
      for the first time in humans that adoptive transfer of Tregs prevented GVHD in 
      the absence of any posttransplantation immunosuppression, promoted lymphoid 
      reconstitution, improved immunity to opportunistic pathogens, and did not weaken 
      the graft-versus-leukemia effect. This study provides evidence that Tregs are a 
      conserved mechanism in humans.
FAU - Di Ianni, Mauro
AU  - Di Ianni M
AD  - Hematology and Clinical Immunology Section, Department of Clinical and 
      Experimental Medicine, University of Perugia, Italy. mauro.diianni@cc.univaq.it
FAU - Falzetti, Franca
AU  - Falzetti F
FAU - Carotti, Alessandra
AU  - Carotti A
FAU - Terenzi, Adelmo
AU  - Terenzi A
FAU - Castellino, Flora
AU  - Castellino F
FAU - Bonifacio, Elisabetta
AU  - Bonifacio E
FAU - Del Papa, Beatrice
AU  - Del Papa B
FAU - Zei, Tiziana
AU  - Zei T
FAU - Ostini, Roberta Iacucci
AU  - Ostini RI
FAU - Cecchini, Debora
AU  - Cecchini D
FAU - Aloisi, Teresa
AU  - Aloisi T
FAU - Perruccio, Katia
AU  - Perruccio K
FAU - Ruggeri, Loredana
AU  - Ruggeri L
FAU - Balucani, Chiara
AU  - Balucani C
FAU - Pierini, Antonio
AU  - Pierini A
FAU - Sportoletti, Paolo
AU  - Sportoletti P
FAU - Aristei, Cynthia
AU  - Aristei C
FAU - Falini, Brunangelo
AU  - Falini B
FAU - Reisner, Yair
AU  - Reisner Y
FAU - Velardi, Andrea
AU  - Velardi A
FAU - Aversa, Franco
AU  - Aversa F
FAU - Martelli, Massimo F
AU  - Martelli MF
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110203
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Adult
MH  - Female
MH  - Graft vs Host Disease/immunology/*prevention & control
MH  - Hematologic Neoplasms/immunology/*therapy
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Histocompatibility/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immune System/immunology/*physiology
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - T-Lymphocytes, Regulatory/immunology/*physiology/transplantation
MH  - Transplantation Conditioning/methods
MH  - Transplantation Immunology/physiology
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2011/02/05 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - S0006-4971(20)45318-2 [pii]
AID - 10.1182/blood-2010-10-311894 [doi]
PST - ppublish
SO  - Blood. 2011 Apr 7;117(14):3921-8. doi: 10.1182/blood-2010-10-311894. Epub 2011 
      Feb 3.