PMID- 21294239
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20220409
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Feb
TI  - Association of peroxisome proliferator-activated receptor gamma coactivator 1 
      alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a 
      meta-analysis.
PG  - 177-84
LID - 10.1002/dmrr.1158 [doi]
AB  - BACKGROUND: The association between peroxisome proliferator-activated receptor 
      gamma coactivator 1 alpha (PPARGC1A) polymorphisms and type 2 diabetes mellitus 
      (T2DM) has been investigated in several studies, but these studies yielded 
      contradictory results. We conducted a meta-analysis to assess the association 
      between three polymorphisms (Gly482Ser, Thr394Thr and Thr612Met) in PPARGC1A and 
      T2DM. METHODS: A literature-based search was conducted to collect data. The 
      additive model was chosen to investigate the association between the three 
      polymorphisms and T2DM. The random effects model was used if there was 
      heterogeneity between studies. In addition, subgroup meta-analyses were made 
      according to the ethnic groups. RESULTS: Twenty-three studies were enrolled in 
      this meta-analysis (7539 cases and 9562 controls for Gly482Ser, 1818 cases and 
      2376 controls for Thr394Thr, 2042 cases and 1289 controls for Thr612Met). In the 
      combined analysis of all eligible studies, a significant association was found 
      between Gly482Ser, Thr394Thr and T2DM with pooled odds ratios 1.19 [95% 
      confidence interval (CI) 1.05-1.34] and 1.33 (95% CI 1.04-1.70), respectively, 
      but great heterogeneity was found between studies. In the subgroup meta-analyses, 
      we found that Gly482Ser and Thr394Thr polymorphisms were associated with the risk 
      of T2DM, and the pooled odds ratios were 1.66 (95% CI 1.28-2.15) and 1.72 (95% CI 
      1.45-2.03), respectively, in the Indian population; no significant evidence was 
      found in the Caucasian and East Asian populations. CONCLUSIONS: This 
      meta-analysis indicated that Gly482Ser and Thr394Thr polymorphisms of PPARGC1A 
      gene were significantly associated with the risk of T2DM, especially in the 
      Indian population. No relationship was found between the Thr612Met and risk of 
      T2DM.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Yang, Ying
AU  - Yang Y
AD  - Department of Evidence Based Medicine and Division of Population Genetics, 
      Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing, China.
FAU - Mo, Xingbo
AU  - Mo X
FAU - Chen, Shufeng
AU  - Chen S
FAU - Lu, Xiangfeng
AU  - Lu X
FAU - Gu, Dongfeng
AU  - Gu D
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Heat-Shock Proteins/*genetics
MH  - Humans
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
MH  - Transcription Factors/*genetics
EDAT- 2011/02/05 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 10.1002/dmrr.1158 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2011 Feb;27(2):177-84. doi: 10.1002/dmrr.1158.