PMID- 21295050
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20220331
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 103
IP  - 2
DP  - 2011 May 3
TI  - 5-methoxy-N,N-di(iso)propyltryptamine hydrochloride (Foxy)-induced cognitive 
      deficits in rat after exposure in adolescence.
PG  - 203-9
LID - 10.1016/j.physbeh.2011.01.021 [doi]
AB  - Foxy or Methoxy Foxy (5-methoxy-N,N-di(iso)propyltryptamine hydrochloride; 
      5-MeO-DIPT) is rapidly gaining popularity among recreational users as a 
      hallucinogenic "designer drug." Unfortunately, much remain unknown about the 
      consequences of its use on neuropsychological development or behavior. During one 
      of two adolescent periods, the rats were given repeated injections of 5 mg/kg or 
      20 mg/kg of 5-MeO-DIPT or a corresponding volume of isotonic saline. After the 
      animals reached adulthood, they were trained and tested on a number of tasks 
      designed to assess the impact of 5-MeO-DIPT, if any, on spatial memory, 
      presumably involving declarative memory systems as well as a nonspatial task that 
      is considered sensitive to disruptions in nondeclarative memory. Both the 
      5-MeO-DIPT- and saline-treated rats were able to master spatial navigation tests 
      where the task included a single goal location and all groups performed 
      comparably on these phases of training and testing. Regardless of exposure level 
      during adolescence, the performance of the drug-treated rats was markedly 
      inferior to that of the control animals on a task where the goal was moved to a 
      new location and on a response learning task, suggesting a lack of flexibility in 
      adapting their responses to changing task demands. Detected reductions in 
      serotonin activity in the forebrain similar to the effects of extensively 
      investigated compounds such as methylenedioxymethamphetamine (MDMA), suggest that 
      5-MeO-DIPT may produce its adverse effects by compromising serotonergic systems 
      in the brain.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Compton, David M
AU  - Compton DM
AD  - Department of Psychology, Palm Beach Atlantic University, PO Box 24708, West Palm 
      Beach, Florida 33416-4708, USA. David_Compton@pba.edu
FAU - Dietrich, Kerri L
AU  - Dietrich KL
FAU - Selinger, Melissa C
AU  - Selinger MC
FAU - Testa, Erin K
AU  - Testa EK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110202
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Hallucinogens)
RN  - 12D06G8W8E (5-methoxy-N,N-diisopropyltryptamine)
RN  - 333DO1RDJY (Serotonin)
RN  - 3VMW6141KC (5-Methoxytryptamine)
SB  - IM
MH  - 5-Methoxytryptamine/adverse effects/*analogs & derivatives
MH  - Age Factors
MH  - Animals
MH  - Cognition Disorders/*chemically induced
MH  - Hallucinogens/*adverse effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Prosencephalon/drug effects/metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Rotarod Performance Test
MH  - Serotonin/metabolism
MH  - Spatial Behavior/drug effects
EDAT- 2011/02/08 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2011/01/14 00:00 [revised]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - S0031-9384(11)00036-9 [pii]
AID - 10.1016/j.physbeh.2011.01.021 [doi]
PST - ppublish
SO  - Physiol Behav. 2011 May 3;103(2):203-9. doi: 10.1016/j.physbeh.2011.01.021. Epub 
      2011 Feb 2.