PMID- 21298090
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20220408
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Jan 26
TI  - Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, 
      dyslipidemia, and insulin resistance among people free of diabetes.
PG  - e15977
LID - 10.1371/journal.pone.0015977 [doi]
LID - e15977
AB  - BACKGROUND: There is emerging evidence that background exposure to persistent 
      organic pollutants (POPs) are important in the development of conditions 
      predisposing to diabetes as well as of type 2 diabetes itself. We recently 
      reported that low dose POPs predicted incident type 2 diabetes in a nested 
      case-control study. The current study examined if low dose POPs predicted future 
      adiposity, dyslipidemia, and insulin resistance among controls without diabetes 
      in that study. METHODOLOGY/PRINCIPAL FINDINGS: The 90 controls were diabetes-free 
      during 20 years follow-up. They were a stratified random sample, enriched with 
      overweight and obese persons. POPs measured in 1987-88 (year 2) sera included 8 
      organochlorine (OC) pesticides, 22 polychlorinated biphenyls (PCBs), and 1 
      polybrominated biphenyl (PBB). Body mass index (BMI), triglycerides, 
      HDL-cholesterol, LDL-cholesterol, and homeostasis model assessment value for 
      insulin resistance (HOMA-IR) were study outcomes at 2005-06 (year 20). The 
      evolution of study outcomes during 18 years by categories of serum concentrations 
      of POPs at year 2 was evaluated by adjusting for the baseline values of outcomes 
      plus potential confounders. Parallel to prediction of type 2 diabetes, many 
      statistically significant associations of POPs with dysmetabolic conditions 
      appeared at low dose, forming inverted U-shaped dose-response relations. Among OC 
      pesticides, p,p'-DDE most consistently predicted higher BMI, triglycerides, and 
      HOMA-IR and lower HDL-cholesterol at year 20 after adjusting for baseline values. 
      Oxychlordane, trans-nonachlor, and hexachlorobenzene also significantly predicted 
      higher triglycerides. Persistent PCBs with >/=7 chlorides predicted higher BMI, 
      triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 with similar 
      dose-response curves. CONCLUSIONS/SIGNIFICANCE: Simultaneous exposure to various 
      POPs in the general population may contribute to development of obesity, 
      dyslipidemia, and insulin resistance, common precursors of type 2 diabetes and 
      cardiovascular diseases. Although obesity is a primary cause of these metabolic 
      abnormalities, POPs exposure may contribute to excess adiposity and other 
      features of dysmetabolism.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Steffes, Michael W
AU  - Steffes MW
FAU - Sjodin, Andreas
AU  - Sjodin A
FAU - Jones, Richard S
AU  - Jones RS
FAU - Needham, Larry L
AU  - Needham LL
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
LA  - eng
GR  - R01 HL053560/HL/NHLBI NIH HHS/United States
GR  - R01-HL-53560/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95095/HC/NHLBI NIH HHS/United States
GR  - N01-HC-48050/HC/NHLBI NIH HHS/United States
GR  - N01HC95095/HL/NHLBI NIH HHS/United States
GR  - N01-HC-48049/HC/NHLBI NIH HHS/United States
GR  - N01HC48050/HL/NHLBI NIH HHS/United States
GR  - N01HC48047/HL/NHLBI NIH HHS/United States
GR  - N01-HC-48048/HC/NHLBI NIH HHS/United States
GR  - N01HC48048/HL/NHLBI NIH HHS/United States
GR  - N01-HC-48047/HC/NHLBI NIH HHS/United States
GR  - N01HC48049/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2
MH  - Dyslipidemias/*etiology
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*blood/toxicity
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/toxicity
MH  - *Insulin Resistance
MH  - Male
MH  - Obesity/*etiology
MH  - Pesticides/blood/*toxicity
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3027626
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/02/08 06:00
MHDA- 2011/08/04 06:00
PMCR- 2011/01/26
CRDT- 2011/02/08 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2010/12/01 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PHST- 2011/01/26 00:00 [pmc-release]
AID - PONE-D-10-02296 [pii]
AID - 10.1371/journal.pone.0015977 [doi]
PST - epublish
SO  - PLoS One. 2011 Jan 26;6(1):e15977. doi: 10.1371/journal.pone.0015977.