PMID- 21299608
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211203
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 58
IP  - 3
DP  - 2011 Feb
TI  - Aurora B kinase expression in laryngeal squamous cell carcinoma and its 
      prognostic implications.
PG  - 368-76
LID - 10.1111/j.1365-2559.2011.03757.x [doi]
AB  - AIMS: To investigate the clinical and prognostic significance of Aurora B in 
      laryngeal squamous cell carcinomas (LSCC). METHODS AND RESULTS: Aurora B protein 
      expression was analysed in 259 LSCC. The proliferation index (Ki67) and the 
      expression of other cell cycle control proteins, such as Aurora A, survivin and 
      p53 was also determined. Aurora B was highly expressed in 55.4% of LSCC. High 
      Aurora B expression levels were correlated with tumour recurrence (P=0.01), death 
      from disease (P=0.05) and decreased disease-free survival (P=0.013) and overall 
      survival (P=0.04). Survivin expression was neither associated with 
      clinicopathological characteristics nor with survival. However, survivin 
      expression in the nucleus paralleled Aurora B expression (P=0.014). Aurora A 
      expression was associated significantly with increased tumour grade (P=0.008). 
      Multivariate analysis indicated that Aurora B was an independent predictor for 
      LSCC-specific disease-free survival [hazard ratio (HR), 2.10; 95% confidence 
      interval (95% CI), 1.25-3.52 (P=0.005)] and overall survival [HR, 1.91; 95% CI 
      1.01-3.34 (P=0.023)]. CONCLUSIONS: Aurora B may be a novel prognostic biomarker 
      for LSCC and a potential therapeutic target in this type of tumour.
CI  - (c) 2011 Blackwell Publishing Limited.
FAU - Garcia-Fernandez, Eugenia
AU  - Garcia-Fernandez E
AD  - Department of Pathology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
FAU - De Diego, Juan I
AU  - De Diego JI
FAU - Collantes-Bellido, Elena
AU  - Collantes-Bellido E
FAU - Mendiola, Marta
AU  - Mendiola M
FAU - Prim, Maria P
AU  - Prim MP
FAU - Perez-Fernandez, Elia
AU  - Perez-Fernandez E
FAU - Miguel-Martin, Maria
AU  - Miguel-Martin M
FAU - Nistal, Manuel
AU  - Nistal M
FAU - Hardisson, David
AU  - Hardisson D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110207
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.11.1 (AURKB protein, human)
RN  - EC 2.7.11.1 (Aurora Kinase B)
RN  - EC 2.7.11.1 (Aurora Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aurora Kinase B
MH  - Aurora Kinases
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*diagnosis/enzymology/mortality
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis/enzymology/mortality
MH  - Larynx/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Protein Serine-Threonine Kinases/*metabolism
EDAT- 2011/02/09 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1111/j.1365-2559.2011.03757.x [doi]
PST - ppublish
SO  - Histopathology. 2011 Feb;58(3):368-76. doi: 10.1111/j.1365-2559.2011.03757.x. 
      Epub 2011 Feb 7.