PMID- 21300465
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20191210
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 81
IP  - 1
DP  - 2011 Sep 1
TI  - Simultaneous 68Ga-DOTATOC-PET/MRI for IMRT treatment planning for meningioma: 
      first experience.
PG  - 277-83
LID - 10.1016/j.ijrobp.2010.10.078 [doi]
AB  - PURPOSE: To evaluate intensity-modulated radiotherapy (IMRT) treatment planning 
      based on simultaneous positron-emission tomography and magnetic resonance imaging 
      (PET/MRI) of meningioma. METHODS AND MATERIALS: A meningioma patient was examined 
      prior to radiotherapy with dedicated planning computed tomography (CT), MRI, 
      PET/CT with gallium-68-labeled DOTATOC (68Ga-DOTATOC), and simultaneous 
      68Ga-DOTATOC-PET/MRI. The first gross target volume (GTV) was defined based on a 
      combination of separate MR and 68Ga-DOTATOC-PET/CT imaging (GTVPET/CT+MR). Then, 
      the simultaneous PET/MR images were used to delineate a second GTV (GTVPET/MR) by 
      following exactly the same delineation strategy. After an isotropic expansion of 
      those volumes by a 4-mm safety margin, the resulting planning target volumes 
      (PTVs) were compared by calculating the intersection volume and the relative 
      complements. A cross-evaluation of IMRT plans was performed, where the treatment 
      plan created for the PTVPET/CT+MR was applied to the PET/MR-based PTVPET/MR. 
      RESULTS: Generally, target volumes for IMRT treatment planning did not differ 
      between MRI plus 68Ga-DOTATOC-PET/CT and simultaneous PET/MR imaging. Only in 
      certain regions of the GTV were differences observed. The overall volume of the 
      PET/MR-based PTV was approximately the same as that obtained from PET/CT data. A 
      small region of infiltrative tumor growth next to the main tumor mass was better 
      visualized with combined PET/MR due to smaller PET voxel sizes and improved 
      recovery. An IMRT treatment plan was optimized for the PTVPET/CT+MR. The 
      evaluation of this plan with respect to the PTVPET/MR showed parts of the target 
      volume that would not have received the full radiation dose after delineation of 
      the tumor, based on simultaneous PET/MR. CONCLUSION: This case showed that 
      differences in target volumes delineated on the basis of separate MR and PET/CT 
      and simultaneous PET/MR may be observed that can have significant consequences 
      for an effectively applied radiotherapy treatment plan.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Thorwarth, Daniela
AU  - Thorwarth D
AD  - Section of Biomedical Physics, University Hospital for Radiation Oncology, 
      Eberhard-Karls-Universitat Tubingen, Tubingen, Germany. 
      daniela.thorwarth@med.uni-tuebingen.de
FAU - Henke, Guido
AU  - Henke G
FAU - Muller, Arndt-Christian
AU  - Muller AC
FAU - Reimold, Matthias
AU  - Reimold M
FAU - Beyer, Thomas
AU  - Beyer T
FAU - Boss, Andreas
AU  - Boss A
FAU - Kolb, Armin
AU  - Kolb A
FAU - Pichler, Bernd
AU  - Pichler B
FAU - Pfannenberg, Christina
AU  - Pfannenberg C
LA  - eng
PT  - Case Reports
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110206
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Ga(III)-DOTATOC)
RN  - 0 (Gallium Radioisotopes)
RN  - 0 (Organometallic Compounds)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Aged
MH  - Female
MH  - Gallium Radioisotopes
MH  - Humans
MH  - Incidental Findings
MH  - Magnetic Resonance Imaging/*methods
MH  - Meningeal Neoplasms/*diagnosis/diagnostic imaging/pathology
MH  - Meningioma/*diagnosis/diagnostic imaging/pathology
MH  - Neoplasm Recurrence, Local/diagnosis/diagnostic imaging/pathology
MH  - Octreotide/*analogs & derivatives
MH  - *Organometallic Compounds
MH  - Positron-Emission Tomography/*methods
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Tomography, X-Ray Computed/methods
MH  - Tumor Burden
EDAT- 2011/02/09 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/06/17 00:00 [received]
PHST- 2010/10/22 00:00 [revised]
PHST- 2010/10/28 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0360-3016(10)03698-9 [pii]
AID - 10.1016/j.ijrobp.2010.10.078 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):277-83. doi: 
      10.1016/j.ijrobp.2010.10.078. Epub 2011 Feb 6.