PMID- 21300829
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20211020
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Print)
IS  - 0066-4804 (Linking)
VI  - 55
IP  - 5
DP  - 2011 May
TI  - Benzimidazole analogs inhibit human herpesvirus 6.
PG  - 2442-5
LID - 10.1128/AAC.01523-10 [doi]
AB  - Several benzimidazole nucleoside analogs, including 
      1H-beta-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 
      1H-beta-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir 
      [MBV]), inhibit the replication of human cytomegalovirus. Neither analog 
      inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional 
      analogs of these compounds were evaluated against both variants of HHV-6, and two 
      L-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more 
      modest inhibition of HHV-6B replication.
FAU - Prichard, Mark N
AU  - Prichard MN
AD  - University of Alabama School of Medicine, 1600 6th Avenue South, 128 Children's 
      Harbor Building, Birmingham, AL 35233, USA. mprichard@peds.uab.edu
FAU - Frederick, Samuel L
AU  - Frederick SL
FAU - Daily, Shannon
AU  - Daily S
FAU - Borysko, Katherine Z
AU  - Borysko KZ
FAU - Townsend, Leroy B
AU  - Townsend LB
FAU - Drach, John C
AU  - Drach JC
FAU - Kern, Earl R
AU  - Kern ER
LA  - eng
GR  - N01AI30049/AI/NIAID NIH HHS/United States
GR  - HHSN2722011000010C/PHS HHS/United States
GR  - HHSN272201100001G/AI/NIAID NIH HHS/United States
GR  - HHSN272201100010C/AI/NIAID NIH HHS/United States
GR  - HHSN272201100001C/AO/NIAID NIH HHS/United States
GR  - N01-AI-30049/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110207
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Antiviral Agents)
RN  - 0 (Benzimidazoles)
SB  - IM
MH  - Antiviral Agents/chemistry/*pharmacology
MH  - Benzimidazoles/chemistry/*pharmacology
MH  - Cytomegalovirus/drug effects
MH  - Herpesvirus 6, Human/*drug effects
MH  - Humans
MH  - Virus Replication/drug effects
PMC - PMC3088228
EDAT- 2011/02/09 06:00
MHDA- 2011/10/05 06:00
PMCR- 2011/11/01
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - AAC.01523-10 [pii]
AID - 1523-10 [pii]
AID - 10.1128/AAC.01523-10 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 2011 May;55(5):2442-5. doi: 10.1128/AAC.01523-10. 
      Epub 2011 Feb 7.