PMID- 21300913
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20231213
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 208
IP  - 2
DP  - 2011 Feb 14
TI  - Aire-dependent production of XCL1 mediates medullary accumulation of thymic 
      dendritic cells and contributes to regulatory T cell development.
PG  - 383-94
LID - 10.1084/jem.20102327 [doi]
AB  - Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the 
      medulla and contribute to the establishment of self-tolerance. However, how the 
      medullary accumulation of tDCs is regulated and involved in self-tolerance is 
      unclear. We show that the chemokine receptor XCR1 is expressed by tDCs, whereas 
      medullary thymic epithelial cells (mTECs) express the ligand XCL1. XCL1-deficient 
      mice are defective in the medullary accumulation of tDCs and the thymic 
      generation of naturally occurring regulatory T cells (nT reg cells). Thymocytes 
      from XCL1-deficient mice elicit dacryoadenitis in nude mice. mTEC expression of 
      XCL1, tDC medullary accumulation, and nT reg cell generation are diminished in 
      Aire-deficient mice. These results indicate that the XCL1-mediated medullary 
      accumulation of tDCs contributes to nT reg cell development and is regulated by 
      Aire.
FAU - Lei, Yu
AU  - Lei Y
AD  - Division of Experimental Immunology, Institute for Genome Research, University of 
      Tokushima, Tokushima, Japan.
FAU - Ripen, Adiratna Mat
AU  - Ripen AM
FAU - Ishimaru, Naozumi
AU  - Ishimaru N
FAU - Ohigashi, Izumi
AU  - Ohigashi I
FAU - Nagasawa, Takashi
AU  - Nagasawa T
FAU - Jeker, Lukas T
AU  - Jeker LT
FAU - Bosl, Michael R
AU  - Bosl MR
FAU - Hollander, Georg A
AU  - Hollander GA
FAU - Hayashi, Yoshio
AU  - Hayashi Y
FAU - Malefyt, Rene de Waal
AU  - Malefyt Rde W
FAU - Nitta, Takeshi
AU  - Nitta T
FAU - Takahama, Yousuke
AU  - Takahama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110207
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, C)
RN  - 0 (Transcription Factors)
RN  - 0 (Xcl1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Chemokines/immunology
MH  - Chemokines, C/*biosynthesis/genetics
MH  - Chemotaxis/immunology
MH  - Dacryocystitis/etiology/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Image Processing, Computer-Assisted
MH  - Mice
MH  - Mice, Nude
MH  - Microscopy, Confocal
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Self Tolerance/*immunology
MH  - T-Lymphocytes, Regulatory/cytology/*immunology
MH  - Thymus Gland/cytology/*immunology
MH  - Transcription Factors/*metabolism
MH  - AIRE Protein
PMC - PMC3039864
EDAT- 2011/02/09 06:00
MHDA- 2011/04/16 06:00
PMCR- 2011/08/14
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
PHST- 2011/08/14 00:00 [pmc-release]
AID - jem.20102327 [pii]
AID - 20102327 [pii]
AID - 10.1084/jem.20102327 [doi]
PST - ppublish
SO  - J Exp Med. 2011 Feb 14;208(2):383-94. doi: 10.1084/jem.20102327. Epub 2011 Feb 7.