PMID- 21301380
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20221207
IS  - 1744-6880 (Electronic)
IS  - 1744-6872 (Linking)
VI  - 21
IP  - 5
DP  - 2011 May
TI  - Positive and negative associations of HLA class I alleles with 
      allopurinol-induced SCARs in Koreans.
PG  - 303-7
LID - 10.1097/FPC.0b013e32834282b8 [doi]
AB  - Recent investigations suggest genetic susceptibility of allopurinol-induced 
      severe cutaneous adverse reactions (SCARs). However, the strength of association 
      was variable according to phenotypes and ethnic backgrounds. To explore genetic 
      markers for allopurinol-induced SCARs in Koreans, we genotyped human leukocyte 
      antigen (HLA) class I alleles of 25 cases of allopurinol-induced SCARs (20 cases 
      of drug-induced hypersensitivity syndrome and five cases of Stevens-Johnson 
      syndrome/toxic epidermal necrolysis) and 57 patients tolerant to allopurinol. 
      Frequencies of B*5801 [92.0 vs. 10.5%, P(c)=2.45x10(-11), odds ratio (OR)=97.8], 
      Cw*0302 (92.0 vs. 12.3%, P(c)=9.39x10(-11), OR=82.1), and A*3303 (88.0 vs. 26.3%, 
      P(c)=3.31x10(-6), OR=20.5) were significantly higher in SCARs compared with 
      tolerant controls. In contrast, A*0201 was not found in SCARs patients despite 
      relatively high frequency in tolerant controls (29.8%). We found strong positive 
      association of HLA-B*5801 and negative association of HLA-A*0201 with the 
      development of allopurinol-induced SCARs in the Korean population.
FAU - Kang, Hye-Ryun
AU  - Kang HR
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Jee, Young Koo
AU  - Jee YK
FAU - Kim, Yon-Soo
AU  - Kim YS
FAU - Lee, Chang Hwa
AU  - Lee CH
FAU - Jung, Jae-Woo
AU  - Jung JW
FAU - Kim, Sae Hoon
AU  - Kim SH
FAU - Park, Heung-Woo
AU  - Park HW
FAU - Chang, Yoon-Seok
AU  - Chang YS
FAU - Jang, In-Jin
AU  - Jang IJ
FAU - Cho, Sang-Heon
AU  - Cho SH
FAU - Min, Kyung-Up
AU  - Min KU
FAU - Kim, Sang-Heon
AU  - Kim SH
FAU - Lee, Kyung Wha
AU  - Lee KW
CN  - Adverse Drug Reaction Research Group in Korea
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacogenet Genomics
JT  - Pharmacogenetics and genomics
JID - 101231005
RN  - 0 (Gout Suppressants)
RN  - 63CZ7GJN5I (Allopurinol)
SB  - IM
EIN - Pharmacogenet Genomics. 2012 Aug;22(8):652
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allopurinol/*adverse effects/therapeutic use
MH  - Asian People/genetics
MH  - Female
MH  - *Genes, MHC Class I
MH  - Genome-Wide Association Study
MH  - Gout Suppressants/*adverse effects/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stevens-Johnson Syndrome/etiology/*genetics
EDAT- 2011/02/09 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1097/FPC.0b013e32834282b8 [doi]
PST - ppublish
SO  - Pharmacogenet Genomics. 2011 May;21(5):303-7. doi: 10.1097/FPC.0b013e32834282b8.