PMID- 2130205
OWN - NLM
STAT- MEDLINE
DCOM- 19911105
LR  - 20131121
IS  - 0025-7680 (Print)
IS  - 0025-7680 (Linking)
VI  - 50
IP  - 3
DP  - 1990
TI  - [Effect of diazoxide on severe pulmonary hypertension].
PG  - 198-204
AB  - Hemodynamic effects were studied after the administration of incremental doses of 
      diazoxide (upper range 300-600 mg) in a group of 15 patients with severe 
      pulmonary hypertension due to different etiologies. No significant changes were 
      found in the mean pulmonary arterial pressure (PAP), "wedge" pressure, right 
      atrial pressure, and right ventricular systolic work index (RVSWI). Significant 
      decreases were found in the mean systemic arterial pressure, pulmonary arterial 
      resistance (PAR), systemic arterial resistance (SAR) and left ventricular 
      systolic work index (LVSWI). Significant increments were found in the cardiac 
      output (Q), heart rate and PAR/SAR ratios (Table 1). A significant correlation 
      was found between Q and SAR pretreatment (r = -0.75, p less than 0.002); PAR and 
      SAR pretreatment (r = 0.69, p less than (0.01); change in SAR vs change in Q 
      produced by diazoxide (r = -0.81, p 0.001); basal PAR/SAR vs D PAP (change 
      pre-post diazoxide) (r = -0.58, p less than 0.05); % PAR/SAR vs % PAP (percent 
      changes in PAR/SAR post diazoxide vs percent change of PAP post diazoxide) (r = 
      0.78, p less than 0.001); D PAP vs D RVSWI (PAP change post diazoxide vs RVSWI 
      change post diazoxide) r = 0.79, p less than 0.001. No significant correlation 
      (either in absolute or in percent values) was found between basal values of 
      pulmonary artery pressure, cardiac output, pulmonary arterial resistance or right 
      ventricular systolic work index vs those produced by the drug in the same 
      parameters. Patients were divided into two groups according to the decrease or 
      increase of pulmonary arterial pressure after diazoxide administration (n = 7 and 
      8, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Raimondi, G A
AU  - Raimondi GA
AD  - Hospital Nacional de Rehabilitacion Respiratoria Maria Ferrer, Buenos Aires, 
      Argentina.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Efecto del diazoxido en la hipertension pulmonar severa.
PL  - Argentina
TA  - Medicina (B Aires)
JT  - Medicina
JID - 0204271
RN  - O5CB12L4FN (Diazoxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/drug effects
MH  - Diazoxide/*therapeutic use
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy
MH  - Lung Volume Measurements
MH  - Middle Aged
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Medicina (B Aires). 1990;50(3):198-204.