PMID- 21302495
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 30
IP  - 12
DP  - 2010 Dec
TI  - [Effects of jiaotai pill and its single components on ectopic fat accumulation in 
      rats with type 2 diabetes mellitus].
PG  - 1297-301
AB  - OBJECTIVE: To study the effects of Jiaotai Pill (JTP) and its single components 
      on ectopic fat accumulation in rats with type 2 diabetes mellitus (T2DM). 
      METHODS: The T2DM model of rat was established by injection of streptozotocin 
      from tail vein and high fat-caloric diet feeding. Model rats were randomly 
      divided into the model group and four treated groups were treated respectively 
      with JTP and its single components, Rhizoma Coptidis, Cinnamon and metformin, via 
      gastric perfusion. Meanwhile, a normal control group was also set up. Body weight 
      (BW), liver index (LI), levels of fasting plasma glucose (FPG), fasting serum 
      insulin (FINS) and insulin resistance index (HOMA-IR), plasma activities of liver 
      associated enzymes (LAE), triglyceride (TG) contents and pathological changes of 
      liver, heart and muscle were determined before and after a 8-week treatment. 
      RESULTS: As compared with the normal rats, BW, LI, LAE activities, HOMA-IR, TG 
      contents of the liver, heart and muscle were all increased in the model rats 
      (P<0.05 or P<0.01), with pathologic appearance of fatty degeneration in different 
      degrees. Compared with the model group, LI, LAE, HOMA-IR, and TG contents in the 
      liver, heart and muscle tissues were decreased in different extents in the four 
      treated groups (P<0.05 or P<0.01), and the histology of tissues in them was 
      restored to near normal. Compared with the metformin treated group, the hepatic 
      and muscular TG contents decreased in the JTP treated group (P<0.01), and the 
      muscular TG content in the Rhizoma Coptidis treated group were lower (P<0.05). 
      And the gamma-GT level in the JTP treated group was the lowest in the three 
      Chinese drugs treated groups (P<0.01). CONCLUSIONS: The disturbances of glucose 
      and lipid metabolism and abnormality of liver function in T2DM rats could be 
      improved by JTP and its single components. The mechanism might be related to 
      their effects in improving insulin resistance and reducing ectopic fat 
      accumulation.
FAU - Gong, Yan-lin
AU  - Gong YL
AD  - Institute of Integrative Traditional Chinese & Western Medicine, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science & Technology, Wuhan 
      430030.
FAU - Lu, Fu-er
AU  - Lu FE
FAU - Dong, Hui
AU  - Dong H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Adiposity/*drug effects
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Insulin Resistance
MH  - Intra-Abdominal Fat/pathology
MH  - Lipid Metabolism/*drug effects
MH  - Liver/pathology
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - *Phytotherapy
MH  - Rats
MH  - Rats, Wistar
EDAT- 2011/02/10 06:00
MHDA- 2013/02/05 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Dec;30(12):1297-301.