PMID- 21302779
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20211020
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Electronic)
IS  - 0094-2405 (Linking)
VI  - 37
IP  - 12
DP  - 2010 Dec
TI  - Joint correction of respiratory motion artifact and partial volume effect in 
      lung/thoracic PET/CT imaging.
PG  - 6221-32
AB  - PURPOSE: Respiratory motion artifacts and partial volume effects (PVEs) are two 
      degrading factors that affect the accuracy of image quantification in PET/CT 
      imaging. In this article, the authors propose a joint motion and PVE correction 
      approach (JMPC) to improve PET quantification by simultaneously correcting for 
      respiratory motion artifacts and PVE in patients with lung/thoracic cancer. The 
      objective of this article is to describe this approach and evaluate its 
      performance using phantom and patient studies. METHODS: The proposed joint 
      correction approach incorporates a model of motion blurring, PVE, and object 
      size/shape. A motion blurring kernel (MBK) is then estimated from the 
      deconvolution of the joint model, while the activity concentration (AC) of the 
      tumor is estimated from the normalization of the derived MBK. To evaluate the 
      performance of this approach, two phantom studies and eight patient studies were 
      performed. In the phantom studies, two motion waveforms-a linear sinusoidal and a 
      circular motion-were used to control the motion of a sphere, while in the patient 
      studies, all participants were instructed to breathe regularly. For the phantom 
      studies, the resultant MBK was compared to the true MBK by measuring a 
      correlation coefficient between the two kernels. The measured sphere AC derived 
      from the proposed method was compared to the true AC as well as the ACs in images 
      exhibiting PVE only and images exhibiting both PVE and motion blurring. For the 
      patient studies, the resultant MBK was compared to the motion extent derived from 
      a 4D-CT study, while the measured tumor AC was compared to the AC in images 
      exhibiting both PVE and motion blurring. RESULTS: For the phantom studies, the 
      estimated MBK approximated the true MBK with an average correlation coefficient 
      of 0.91. The tumor ACs following the joint correction technique were similar to 
      the true AC with an average difference of 2%. Furthermore, the tumor ACs on the 
      PVE only images and images with both motion blur and PVE effects were, on 
      average, 75% and 47.5% (10%) of the true AC, respectively, for the linear 
      (circular) motion phantom study. For the patient studies, the maximum and mean 
      AC/SUV on the PET images following the joint correction are, on average, 
      increased by 125.9% and 371.6%, respectively, when compared to the PET images 
      with both PVE and motion. The motion extents measured from the derived MBK and 
      4D-CT exhibited an average difference of 1.9 mm. CONCLUSIONS: The proposed joint 
      correction approach can improve the accuracy of PET quantification by 
      simultaneously compensating for the respiratory motion artifacts and PVE in 
      lung/thoracic PET/CT imaging.
FAU - Chang, Guoping
AU  - Chang G
AD  - Electrical and Computer Engineering, Rice University, Houston, Texas 77005, USA.
FAU - Chang, Tingting
AU  - Chang T
FAU - Pan, Tinsu
AU  - Pan T
FAU - Clark, John W Jr
AU  - Clark JW Jr
FAU - Mawlawi, Osama R
AU  - Mawlawi OR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - *Artifacts
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Lung/diagnostic imaging/physiopathology
MH  - Lung Neoplasms/diagnostic imaging/physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Movement
MH  - Phantoms, Imaging
MH  - Positron-Emission Tomography/*methods
MH  - Radiography, Thoracic/*methods
MH  - *Respiration
MH  - Thorax/diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC3820620
EDAT- 2011/02/10 06:00
MHDA- 2011/03/12 06:00
PMCR- 2011/12/01
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - 006012MPH [pii]
AID - 10.1118/1.3512780 [doi]
PST - ppublish
SO  - Med Phys. 2010 Dec;37(12):6221-32. doi: 10.1118/1.3512780.