PMID- 21303426
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20221207
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 16
IP  - 4
DP  - 2011 May
TI  - Genetic predisposition to diffuse panbronchiolitis.
PG  - 581-8
LID - 10.1111/j.1440-1843.2011.01946.x [doi]
AB  - Diffuse panbronchiolitis is characterized by chronic inflammation in respiratory 
      bronchioles and sinobronchial infection. The pathophysiology accompanying the 
      persistent bacterial infection is noteworthy for the accumulation of lymphocytes 
      and foamy macrophages around the small airways, for mucus hypersecretion, and for 
      the number of neutrophils in the large airways. Until the establishment of 
      long-term macrolide therapy, the prognosis was generally poor. Case studies of 
      diffuse panbronchiolitis in East Asians, including Japanese, Koreans and Chinese, 
      have frequently been reported, and genetic predisposition to the disease has been 
      assumed in Asians. Immunogenetic studies revealed a strong association with human 
      leukocyte antigen (HLA)-B54 in Japanese, whereas an association with HLA-A11 was 
      reported in Koreans. These findings imply that a major susceptibility gene may be 
      located between the HLA-A and HLA-B loci on the short arm of human chromosome 6. 
      We have recently cloned novel mucin-like genes in this candidate region. In 
      addition to accumulated knowledge of classical HLA genes and mucin genes, further 
      analysis of newly identified genes may provide insights into the pathogenesis of 
      the disease.
CI  - (c) 2011 The Authors. Respirology (c) 2011 Asian Pacific Society of Respirology.
FAU - Keicho, Naoto
AU  - Keicho N
AD  - Department of Respiratory Diseases, Research Institute, National Center for 
      Global Health and Medicine, Tokyo, Japan. nkeicho-tky@umin.ac.jp
FAU - Hijikata, Minako
AU  - Hijikata M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (HLA Antigens)
RN  - 0 (Macrolides)
RN  - 0 (Mucins)
RN  - Diffuse panbronchiolitis
SB  - IM
MH  - *Bronchiolitis/drug therapy/genetics/immunology
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Cystic Fibrosis/genetics/immunology
MH  - Asia, Eastern
MH  - Female
MH  - Foam Cells/drug effects/immunology
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/genetics/immunology
MH  - *Haemophilus Infections/drug therapy/genetics/immunology
MH  - Humans
MH  - Lymphocytes/drug effects/immunology
MH  - Macrolides/therapeutic use
MH  - Male
MH  - Mucins/genetics/immunology
MH  - Mucus/drug effects/metabolism
MH  - Neutrophils/drug effects/immunology
MH  - Pacific Islands
MH  - Polymorphism, Genetic
EDAT- 2011/02/10 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
AID - 10.1111/j.1440-1843.2011.01946.x [doi]
PST - ppublish
SO  - Respirology. 2011 May;16(4):581-8. doi: 10.1111/j.1440-1843.2011.01946.x.