PMID- 21304246
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20110421
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 58
IP  - 1
DP  - 2011
TI  - Caloric restriction and antiaging effects.
PG  - 42-8
LID - 10.1159/000323748 [doi]
AB  - Caloric restriction (CR) is widely used to study aging processes. It is a simple 
      and highly reproducible method for delaying the aging process, preventing the 
      onset of aging-related diseases and extending average or maximum lifespan. 
      However, the mechanism underlying these effects of CR is still not clear. CR can 
      inhibit growth, reduce body size and maintain a low body temperature. At the same 
      time, there is a measurable decrease in the volume of adipose tissue, 
      hyperglycemia and hyperinsulinemia, accompanied by modifications of lipid and 
      energy metabolism and increased resistance to endogenous and extraneous stress. 
      The metabolic changes induced by dietary restriction, the inhibition of fat 
      deposition in nonadipose tissue and the effects on signal transduction are 
      considered the most likely candidates for mechanisms underlying the effects of 
      CR.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Xiang, Lan
AU  - Xiang L
AD  - School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 
      China.
FAU - He, Guoqing
AU  - He G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110208
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Dietary Proteins)
RN  - 0 (Lipids)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Aging/*metabolism
MH  - Animals
MH  - Body Temperature
MH  - *Caloric Restriction
MH  - Diet, Reducing
MH  - Dietary Proteins/*administration & dosage
MH  - *Energy Metabolism
MH  - Humans
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Lipids/blood
MH  - Neurosecretory Systems/metabolism
MH  - Signal Transduction
EDAT- 2011/02/10 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/02/10 06:00
PHST- 2009/12/03 00:00 [received]
PHST- 2010/12/16 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 000323748 [pii]
AID - 10.1159/000323748 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2011;58(1):42-8. doi: 10.1159/000323748. Epub 2011 Feb 8.