PMID- 21305276
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20240322
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 63
IP  - 6
DP  - 2011 Jun
TI  - Functional classification of class II human leukocyte antigen (HLA) molecules 
      reveals seven different supertypes and a surprising degree of repertoire sharing 
      across supertypes.
PG  - 325-35
LID - 10.1007/s00251-011-0513-0 [doi]
AB  - Previous studies have attempted to define human leukocyte antigen (HLA) class II 
      supertypes, analogous to the case for class I, on the basis of shared 
      peptide-binding motifs or structure. In the present study, we determined the 
      binding capacity of a large panel of non-redundant peptides for a set of 27 
      common HLA DR, DQ, and DP molecules. The measured binding data were then used to 
      define class II supertypes on the basis of shared binding repertoires. Seven 
      different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were 
      defined. The molecules associated with the respective supertypes fell largely 
      along lines defined by MHC locus and reflect, in broad terms, commonalities in 
      reported peptide-binding motifs. Repertoire overlaps between molecules within the 
      same class II supertype were found to be similar in magnitude to what has been 
      observed for HLA class I supertypes. Surprisingly, however, the degree to which 
      repertoires between molecules in the different class II supertypes also 
      overlapped was found to be five to tenfold higher than repertoire overlaps noted 
      between molecules in different class I supertypes. These results highlight a high 
      degree of repertoire overlap amongst all HLA class II molecules, perhaps 
      reflecting binding in multiple registers, and more pronounced dependence on 
      backbone interactions rather than peptide anchor residues. This fundamental 
      difference between HLA class I and class II would not have been predicted on the 
      basis of analysis of either binding motifs or the sequence/predicted structures 
      of the HLA molecules.
FAU - Greenbaum, Jason
AU  - Greenbaum J
AD  - La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 
      92037, USA.
FAU - Sidney, John
AU  - Sidney J
FAU - Chung, Jolan
AU  - Chung J
FAU - Brander, Christian
AU  - Brander C
FAU - Peters, Bjoern
AU  - Peters B
FAU - Sette, Alessandro
AU  - Sette A
LA  - eng
GR  - HHSN272200700048C/AI/NIAID NIH HHS/United States
GR  - HHSN272200900042C/AI/NIAID NIH HHS/United States
GR  - HHSN272200900044C/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110209
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Epitopes)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - Amino Acid Motifs
MH  - Epitopes/metabolism
MH  - Genes, MHC Class II
MH  - HLA-D Antigens/*classification/genetics/*metabolism
MH  - HLA-DP Antigens/classification/genetics/metabolism
MH  - HLA-DQ Antigens/classification/genetics/metabolism
MH  - HLA-DR Antigens/classification/genetics/metabolism
MH  - Humans
MH  - Protein Binding
PMC - PMC3626422
MID - NIHMS406940
EDAT- 2011/02/10 06:00
MHDA- 2011/07/06 06:00
PMCR- 2013/04/15
CRDT- 2011/02/10 06:00
PHST- 2010/11/04 00:00 [received]
PHST- 2011/01/06 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
PHST- 2013/04/15 00:00 [pmc-release]
AID - 10.1007/s00251-011-0513-0 [doi]
PST - ppublish
SO  - Immunogenetics. 2011 Jun;63(6):325-35. doi: 10.1007/s00251-011-0513-0. Epub 2011 
      Feb 9.