PMID- 21306285
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20181201
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Apr
TI  - Proactive multiple cardiovascular risk factor management compared with usual care 
      in patients with hypertension and additional risk factors: the CRUCIAL trial.
PG  - 821-33
LID - 10.1185/03007995.2011.555754 [doi]
AB  - OBJECTIVE: To investigate whether a proactive multifactorial risk factor 
      intervention strategy using single-pill amlodipine/atorvastatin (5/10, 10/10 mg) 
      in addition to other antihypertensive and lipid-lowering therapy, as required, 
      resulted in greater reduction in calculated Framingham 10-year coronary heart 
      disease (CHD) risk compared with usual care (UC) after 52-weeks treatment. 
      RESEARCH DESIGN AND METHODS: Prospective, multinational, open-label, cluster 
      randomized trial, with the investigator as the unit of randomization. Eligible 
      hypertensive patients were 35-79 years of age, with >/=3 additional cardiovascular 
      risk factors, but no history of CHD and baseline total cholesterol (TC) 
      </=6.5 mmol/l. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov ; trial 
      identifier NCT00407537. MAIN OUTCOME MEASURE: The primary endpoint was calculated 
      Framingham 10-year CHD risk at 52 weeks. RESULTS: Of the 140 randomized sites, 
      136 sites contributed 1461 patients. Mean baseline age and low-density 
      lipoprotein cholesterol (LDL-C) were comparable between treatment arms. Mean 
      baseline BP (150.3/89.7 vs. 144.3/86.5 mmHg) and Framingham CHD risk (20.0 vs. 
      18.1%) were higher in the proactive intervention versus the UC arm (p < 0.002 for 
      both). At week 52, mean CHD risk was 12.5% in the proactive intervention arm and 
      16.3% in the UC arm (p < 0.001). The difference, observed at weeks 16 and 52, was 
      primarily driven by significant differences in systolic BP and in TC between the 
      two arms. Overall, adverse events (AEs) were reported in 48.8% and 44.0% of 
      patients in the proactive intervention and the UC arm, respectively. Although 
      there were differences in the incidence of AEs between the treatment arms, the AE 
      profile in the proactive intervention arm was consistent with previous safety 
      experience for this medication. CONCLUSIONS: A proactive multifactorial risk 
      factor intervention strategy that simultaneously treated both BP and cholesterol 
      regardless of individual risk factors per se, is more effective in reducing 
      calculated Framingham 10-year CHD risk than UC in patients with hypertension and 
      additional risk factors.
FAU - Zamorano, Jose
AU  - Zamorano J
AD  - Hospital Clinico San Carlos, Madrid, Spain. zamorano@secardiologia.es
FAU - Erdine, Serap
AU  - Erdine S
FAU - Pavia, Abel
AU  - Pavia A
FAU - Kim, Jae-Hyung
AU  - Kim JH
FAU - Al-Khadra, Ayman
AU  - Al-Khadra A
FAU - Westergaard, Mogens
AU  - Westergaard M
FAU - Sutradhar, Santosh
AU  - Sutradhar S
FAU - Yunis, Carla
AU  - Yunis C
CN  - CRUCIAL Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00407537
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110210
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Pyrroles)
RN  - 1J444QC288 (Amlodipine)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amlodipine/administration & dosage/adverse effects
MH  - Antihypertensive Agents/*administration & dosage/adverse effects
MH  - Atorvastatin
MH  - Cardiovascular Diseases/etiology/*prevention & control
MH  - Drug Combinations
MH  - Female
MH  - Follow-Up Studies
MH  - Heptanoic Acids/administration & dosage/adverse effects
MH  - Humans
MH  - Hypertension/*complications/*therapy
MH  - Hypolipidemic Agents/administration & dosage/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Preventive Health Services/*methods/statistics & numerical data
MH  - Pyrroles/administration & dosage/adverse effects
MH  - Risk Factors
MH  - *Standard of Care/statistics & numerical data
FIR - Gamboa-Garro, Roberto
IR  - Gamboa-Garro R
FIR - Cespedes-Vargas, Javier
IR  - Cespedes-Vargas J
FIR - Sancez-Soto, Catalina
IR  - Sancez-Soto C
FIR - Moya-Rodriguez, Javier
IR  - Moya-Rodriguez J
FIR - Gonzalez-Rojas, Linette
IR  - Gonzalez-Rojas L
FIR - Jones-Chacon, Miguel Angel
IR  - Jones-Chacon MA
FIR - Ramirez, Luis Carlos
IR  - Ramirez LC
FIR - Cob-Sanchez, Alejandro
IR  - Cob-Sanchez A
FIR - Dengo-Sotela, Georgina
IR  - Dengo-Sotela G
FIR - Apestegui, Ignacio Gamboa
IR  - Apestegui IG
FIR - Sucaet, Brigitte
IR  - Sucaet B
FIR - Slon-Hitti, Claudio
IR  - Slon-Hitti C
FIR - Mesen, Guiselle
IR  - Mesen G
FIR - Zumbado, Rodrigo
IR  - Zumbado R
FIR - Tortos-Guzman, Jaime
IR  - Tortos-Guzman J
FIR - Echeverri-McCandless, Ann
IR  - Echeverri-McCandless A
FIR - Martinez-Elizondo, Marcela
IR  - Martinez-Elizondo M
FIR - Vinocour-Fornieri, Mary
IR  - Vinocour-Fornieri M
FIR - Duran-Ramirez, Marisol
IR  - Duran-Ramirez M
FIR - Yung-Li, Grace
IR  - Yung-Li G
FIR - Bokarica, Dubravka
IR  - Bokarica D
FIR - Bezdrov, Merim
IR  - Bezdrov M
FIR - Car, Ines
IR  - Car I
FIR - Cikac, Tatjana
IR  - Cikac T
FIR - Cop, Renata
IR  - Cop R
FIR - Hrandek, Brigita Haubrich
IR  - Hrandek BH
FIR - Javoric, Jadranka
IR  - Javoric J
FIR - Kotur, Goran
IR  - Kotur G
FIR - Kranjcevic, Ksenija
IR  - Kranjcevic K
FIR - Lazic, Goran
IR  - Lazic G
FIR - Maravic, Zoran
IR  - Maravic Z
FIR - Margetic, Srecko
IR  - Margetic S
FIR - Primorac, Lidija
IR  - Primorac L
FIR - Prlina, Mladen
IR  - Prlina M
FIR - Smiciklas, Nada Franic
IR  - Smiciklas NF
FIR - Grilec, Biserka
IR  - Grilec B
FIR - Stritof, Mladen
IR  - Stritof M
FIR - Smiciklas, Nada Franic
IR  - Smiciklas NF
FIR - Vivoda, Zrinka Bradicic
IR  - Vivoda ZB
FIR - Vrdoljak, Davorka
IR  - Vrdoljak D
FIR - Herle, Petr
IR  - Herle P
FIR - Kos, Pavel
IR  - Kos P
FIR - Marek, Vladimir
IR  - Marek V
FIR - Miskovska, Zuzana
IR  - Miskovska Z
FIR - Miskovsky, Jan
IR  - Miskovsky J
FIR - Moravcikova, Dana
IR  - Moravcikova D
FIR - Motlikova, Eliska
IR  - Motlikova E
FIR - Hanusova, Ivana
IR  - Hanusova I
FIR - Nejedla, Anna
IR  - Nejedla A
FIR - Seifert, Bohumil
IR  - Seifert B
FIR - Youngova, Adriana
IR  - Youngova A
FIR - Skala, Bohumil
IR  - Skala B
FIR - Vecerek, Michal
IR  - Vecerek M
FIR - Winklerova, Jitka
IR  - Winklerova J
FIR - Almonte, Claudio
IR  - Almonte C
FIR - Diez, Ysmenia
IR  - Diez Y
FIR - Nunez, Elaine
IR  - Nunez E
FIR - Gonzalez-Medina, Angel
IR  - Gonzalez-Medina A
FIR - Suarez-Fuster, Laiden
IR  - Suarez-Fuster L
FIR - Pichardo, Rafael
IR  - Pichardo R
FIR - Rodriguez, Carmen
IR  - Rodriguez C
FIR - Sanchez, Ana
IR  - Sanchez A
FIR - Chandradin, Chandramin
IR  - Chandradin C
FIR - Wardoyo, Ananda
IR  - Wardoyo A
FIR - Harahap, Mei Lestari
IR  - Harahap ML
FIR - Achyar, Achyar
IR  - Achyar A
FIR - Kusmana, Dede
IR  - Kusmana D
FIR - Dakota, Iwan
IR  - Dakota I
FIR - Radi, Basuni
IR  - Radi B
FIR - Lukito, Antonia Anna
IR  - Lukito AA
FIR - Eddy, Edward
IR  - Eddy E
FIR - Makmun, Lukman Hakim
IR  - Makmun LH
FIR - Nasution, Sally Aman
IR  - Nasution SA
FIR - Martanto, Erwan
IR  - Martanto E
FIR - Achmad, Chaerul
IR  - Achmad C
FIR - Antono, Eko
IR  - Antono E
FIR - Rifqi, Sodiqur
IR  - Rifqi S
FIR - Herminingsih, Susi
IR  - Herminingsih S
FIR - Yogiarto, R Mohammad
IR  - Yogiarto RM
FIR - Sumantri, Djoko
IR  - Sumantri D
FIR - Subagjo, Agus
IR  - Subagjo A
FIR - Albatayneh, Ahnaf
IR  - Albatayneh A
FIR - Khatib, Nidal
IR  - Khatib N
FIR - Qaqa, Zakaria
IR  - Qaqa Z
FIR - Saleh, Akram Al
IR  - Saleh AA
FIR - Baek, Sang-Hong
IR  - Baek SH
FIR - Baek, Ju-Yeol
IR  - Baek JY
FIR - Jung, Hae Ok
IR  - Jung HO
FIR - Kim, Pum-Joon
IR  - Kim PJ
FIR - Park, Mahn-Won
IR  - Park MW
FIR - Yoon, Seong Gyu
IR  - Yoon SG
FIR - Cho, Seung-Yun
IR  - Cho SY
FIR - Lee, Sang-Hak
IR  - Lee SH
FIR - Park, Sung Ha
IR  - Park SH
FIR - Hur, Seung-Ho
IR  - Hur SH
FIR - Cho, Yun-Kyeong
IR  - Cho YK
FIR - Kim, Hyung-Seop
IR  - Kim HS
FIR - Kim, Kwon-Bae
IR  - Kim KB
FIR - Nam, Chang-Wook
IR  - Nam CW
FIR - Jeong, Myung Ho
IR  - Jeong MH
FIR - Kang, Duk-Hyun
IR  - Kang DH
FIR - Kim, Cheol Ho
IR  - Kim CH
FIR - Chae, In-Ho
IR  - Chae IH
FIR - Cho, Young-Seok
IR  - Cho YS
FIR - Choi, Dong-Ju
IR  - Choi DJ
FIR - Kim, Kwang-Il
IR  - Kim KI
FIR - Youn, Tae-Jin
IR  - Youn TJ
FIR - Kim, Dong-Soo
IR  - Kim DS
FIR - Kim, Dae-Kyeong
IR  - Kim DK
FIR - Kim, Seong-Man
IR  - Kim SM
FIR - Yang, Tae-Hyun
IR  - Yang TH
FIR - Kim, Kee-Sik
IR  - Kim KS
FIR - Chang, Sung-Gug
IR  - Chang SG
FIR - Choi, Ji-Yong
IR  - Choi JY
FIR - Lee, Jin-Bae
IR  - Lee JB
FIR - Lee, Young-Soo
IR  - Lee YS
FIR - Ryu, Jae-Kean
IR  - Ryu JK
FIR - Kim, Moo-Hyun
IR  - Kim MH
FIR - Cha, Kwang-Soo
IR  - Cha KS
FIR - Koh, Kwang-Kon
IR  - Koh KK
FIR - Kwon, Hyuck Moon
IR  - Kwon HM
FIR - Hong, Bum Kee
IR  - Hong BK
FIR - Min, Pil-Ki
IR  - Min PK
FIR - Rim, Se-Joong
IR  - Rim SJ
FIR - Yoon, Young Won
IR  - Yoon YW
FIR - Lee, Seung-Hwan
IR  - Lee SH
FIR - Kim, Jang-Young
IR  - Kim JY
FIR - Lee, Mi Young
IR  - Lee MY
FIR - Shin, Young Goo
IR  - Shin YG
FIR - Yoo, Byung-Su
IR  - Yoo BS
FIR - Oh, Byung-Hee
IR  - Oh BH
FIR - Lee, Hae-Young
IR  - Lee HY
FIR - Park, Jae-Hyeong
IR  - Park JH
FIR - Lee, Jae-Hwan
IR  - Lee JH
FIR - Park, Seung Woo
IR  - Park SW
FIR - Sung, Jidong
IR  - Sung J
FIR - Seo, Hong-Seog
IR  - Seo HS
FIR - Kim, Eung Ju
IR  - Kim EJ
FIR - Shim, Wan-Joo
IR  - Shim WJ
FIR - Park, Seong-Mi
IR  - Park SM
FIR - Tahk, Seung-Jea
IR  - Tahk SJ
FIR - Choi, Byoung-Joo
IR  - Choi BJ
FIR - Choi, So-Yeon
IR  - Choi SY
FIR - Choi, Un-Jung
IR  - Choi UJ
FIR - Hwang, Jung-Won
IR  - Hwang JW
FIR - Kang, Soo-Jin
IR  - Kang SJ
FIR - Lim, Hong-Seok
IR  - Lim HS
FIR - Shin, Joon-Han
IR  - Shin JH
FIR - Woo, Sung-Il
IR  - Woo SI
FIR - Yoon, Myeong-Ho
IR  - Yoon MH
FIR - Akbar, Mousa
IR  - Akbar M
FIR - Petrovski, Plamen
IR  - Petrovski P
FIR - Yassin, Khalid
IR  - Yassin K
FIR - Zubaid, Mohammed
IR  - Zubaid M
FIR - Ali, Amr
IR  - Ali A
FIR - Adhami, Atika
IR  - Adhami A
FIR - El Bayeh, Hamid
IR  - El Bayeh H
FIR - Chouairi, Salah
IR  - Chouairi S
FIR - Sarkis, Antoine Saadallah
IR  - Sarkis AS
FIR - Aziz, Aznida Firzah Abdul
IR  - Aziz A
FIR - Ahmad, Saharuddin
IR  - Ahmad S
FIR - Hashim, Nor Asiah
IR  - Hashim NA
FIR - Kwa, Siew-Kim
IR  - Kwa SK
FIR - Ismail, Mastura
IR  - Ismail M
FIR - Lee, Wah-Yen
IR  - Lee WY
FIR - Sathay, Selvarajah
IR  - Sathay S
FIR - Rajathurai, Chandravathana
IR  - Rajathurai C
FIR - Xavier, Gnanasegaran
IR  - Xavier G
FIR - Alvarado-Ruiz, Ricardo
IR  - Alvarado-Ruiz R
FIR - Reyes-Sanchez, Roxana
IR  - Reyes-Sanchez R
FIR - Sida-Perez, Paulina
IR  - Sida-Perez P
FIR - Cabrera-Jardines, Ricardo
IR  - Cabrera-Jardines R
FIR - Cruz-Diaz, Ambrosio
IR  - Cruz-Diaz A
FIR - Rangel-Rojo, Francisco Javier
IR  - Rangel-Rojo FJ
FIR - Duarte-Vega, Manuel
IR  - Duarte-Vega M
FIR - Zamora-Angulo, Luis Enrique
IR  - Zamora-Angulo LE
FIR - Gonzalez-Ortiz, Manuel
IR  - Gonzalez-Ortiz M
FIR - Guerra-Guevaraq, Karla P
IR  - Guerra-Guevaraq KP
FIR - Robles, Jose Antonio
IR  - Robles JA
FIR - Halley-Castillo, Maria Elizabeth
IR  - Halley-Castillo ME
FIR - Aranza-Doniz, Carlos
IR  - Aranza-Doniz C
FIR - Archundia-Cabanez, Heidy Marlene
IR  - Archundia-Cabanez HM
FIR - Lopez-Morales, Carlos de Jesus
IR  - Lopez-Morales Cde J
FIR - Perez-Moreno, David
IR  - Perez-Moreno D
FIR - Meaney-Martinez, Alejandra
IR  - Meaney-Martinez A
FIR - Rodriguez-Briones, Ignacio
IR  - Rodriguez-Briones I
FIR - Delgado-Galicia, Erika Araida
IR  - Delgado-Galicia EA
FIR - Quintero, Suyin
IR  - Quintero S
FIR - Trujillo, Rita
IR  - Trujillo R
FIR - Guardia, Carmen
IR  - Guardia C
FIR - Jaen, Ycly
IR  - Jaen Y
FIR - Lim-Abrahan, Mary Anne
IR  - Lim-Abrahan MA
FIR - Fernando, Karla Kristine Silverio
IR  - Fernando KK
FIR - Panelo, Araceli
IR  - Panelo A
FIR - Agra, Jeimeen
IR  - Agra J
FIR - Punzalan, Felix Eduardo R
IR  - Punzalan FE
FIR - Aquino-Nablo, Mary Dawn
IR  - Aquino-Nablo MD
FIR - Jocson, Gabriel B 3rd
IR  - Jocson GB 3rd
FIR - Roasa, Elizabeth L
IR  - Roasa EL
FIR - Garcia, Maren
IR  - Garcia M
FIR - Sy, Rody G
IR  - Sy RG
FIR - Chua, Philip U
IR  - Chua PU
FIR - Vicaldo, Efren R
IR  - Vicaldo ER
FIR - Akhmedzhanov, Nadir M
IR  - Akhmedzhanov NM
FIR - Kachanova, Nadezhda
IR  - Kachanova N
FIR - Aroutyunov, Grigory P
IR  - Aroutyunov GP
FIR - Chernyavskaya, Tatiana K
IR  - Chernyavskaya TK
FIR - Meskhidze, Ekaterina B
IR  - Meskhidze EB
FIR - Bart, Boris Y
IR  - Bart BY
FIR - Mikhailusova, Marina P
IR  - Mikhailusova MP
FIR - Runikhina, Nadezhda K
IR  - Runikhina NK
FIR - Egorova, Lyudmila P
IR  - Egorova LP
FIR - Maslakova, Drosida
IR  - Maslakova D
FIR - Sychova, Yuliya A
IR  - Sychova YA
FIR - Karpov, Yuri B
IR  - Karpov YB
FIR - Garshin, Boris B
IR  - Garshin BB
FIR - Kosenko, Boris V
IR  - Kosenko BV
FIR - Kurakova, Elena N
IR  - Kurakova EN
FIR - Kostenko, Viktor A
IR  - Kostenko VA
FIR - Bokovin, Nikolay
IR  - Bokovin N
FIR - Tumarov, Farid
IR  - Tumarov F
FIR - Lopatin, Yuri M
IR  - Lopatin YM
FIR - Ilyukhin, Oleg V
IR  - Ilyukhin OV
FIR - Zavodchikova, Elena N
IR  - Zavodchikova EN
FIR - Moiseyev, Valentin S
IR  - Moiseyev VS
FIR - Kobalava, Zhanna
IR  - Kobalava Z
FIR - Korovina, Elena P
IR  - Korovina EP
FIR - Rubanova, Anna
IR  - Rubanova A
FIR - Villevalde, Svetlana V
IR  - Villevalde SV
FIR - Petrov, Alexander A
IR  - Petrov AA
FIR - Shubik, Yuri V
IR  - Shubik YV
FIR - Aparina, Irina
IR  - Aparina I
FIR - Solovieva, Zinaida
IR  - Solovieva Z
FIR - Vishnevskiy, Alexander
IR  - Vishnevskiy A
FIR - Bershtein, Leonid
IR  - Bershtein L
FIR - Kositcyn, Dmitry V
IR  - Kositcyn DV
FIR - Molotkova, Elena N
IR  - Molotkova EN
FIR - Smirnov, Grigory B
IR  - Smirnov GB
FIR - Terskikh, Mikhail
IR  - Terskikh M
FIR - Yusupov, Aynar S
IR  - Yusupov AS
FIR - Titkov, Yury S
IR  - Titkov YS
FIR - Zharkova, Lyudmila P
IR  - Zharkova LP
FIR - Andreeva, Irina V
IR  - Andreeva IV
FIR - Ilyin, Denis V
IR  - Ilyin DV
FIR - Zrazhevsky, Konstantin N
IR  - Zrazhevsky KN
FIR - Paltsman, Zhanna V
IR  - Paltsman ZV
FIR - Rodina, Natalya A
IR  - Rodina NA
FIR - Chen, Jung-fu
IR  - Chen JF
FIR - Kuo, Ming-Chun
IR  - Kuo MC
FIR - Chen, Zhih-Cherng
IR  - Chen ZC
FIR - Ko, Yu-Lin
IR  - Ko YL
FIR - Lai, Wen-ter
IR  - Lai WT
FIR - Lee, Kun-Tai
IR  - Lee KT
FIR - Lin, Li-Jen
IR  - Lin LJ
FIR - Ueng, Kwo-Chang
IR  - Ueng KC
FIR - Tseng, Chuen-den
IR  - Tseng CD
FIR - Jeng, Jiann-Shing
IR  - Jeng JS
FIR - Wang, Yi-Chih
IR  - Wang YC
FIR - Wang, Kuo-Yang
IR  - Wang KY
FIR - Assawawitoontip, Surin
IR  - Assawawitoontip S
FIR - Sakulsaengprapha, Thanavit
IR  - Sakulsaengprapha T
FIR - Wadhanakul, Kidaphol
IR  - Wadhanakul K
FIR - Thongouppakarn, Puntudis
IR  - Thongouppakarn P
FIR - Bodur, Hakan Alp
IR  - Bodur HA
FIR - Tunca, Mehmet
IR  - Tunca M
FIR - Guler, Kerim
IR  - Guler K
FIR - Akkaya, Vakur
IR  - Akkaya V
FIR - Kumbasar, Abdulbaki
IR  - Kumbasar A
FIR - Cengiz, Ismail
IR  - Cengiz I
FIR - Ergen, Abdulkadir
IR  - Ergen A
FIR - Sertkaya, Serap
IR  - Sertkaya S
FIR - Akpolat, Aysegul Zobi
IR  - Akpolat A
FIR - Sonbahar, Mehmet
IR  - Sonbahar M
FIR - Yildrim, Ali
IR  - Yildrim A
FIR - Tukek, Tufan
IR  - Tukek T
FIR - Cakirca, Mustafa
IR  - Cakirca M
FIR - Cikrikcioglu, Mehmet Ali
IR  - Cikrikcioglu MA
FIR - Kurt, Tulin
IR  - Kurt T
FIR - Kurtulmus, Neslihan
IR  - Kurtulmus N
FIR - Tunckale, Aydin
IR  - Tunckale A
FIR - Curgunlu, Asli
IR  - Curgunlu A
FIR - Afendi, Bashar
IR  - Afendi B
FIR - El Houni, Ali
IR  - El Houni A
FIR - Naeemi, Abdullah Al
IR  - Naeemi AA
FIR - Brek, Azan Salim Bin
IR  - Brek AS
FIR - Feiruz, Amna
IR  - Feiruz A
FIR - Gabroun, Ahmed
IR  - Gabroun A
FIR - Kaddaha, Ghaida
IR  - Kaddaha G
FIR - Matto, Sameem
IR  - Matto S
FIR - Antepara, Norka
IR  - Antepara N
FIR - Jimenez, Alvaro
IR  - Jimenez A
FIR - Chazzim, Gerardo
IR  - Chazzim G
FIR - Martinez, Evelyn
IR  - Martinez E
FIR - Delgado, Antonio Javier
IR  - Delgado AJ
FIR - Guzman, Mirecly
IR  - Guzman M
FIR - Delgado, Carlos Luis
IR  - Delgado CL
FIR - Ribaldi, Jose David
IR  - Ribaldi JD
EDAT- 2011/02/11 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1185/03007995.2011.555754 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2011 Apr;27(4):821-33. doi: 10.1185/03007995.2011.555754. Epub 
      2011 Feb 10.