PMID- 21307320
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 105
IP  - 4
DP  - 2011 Apr
TI  - Improved stimulus representation by short interspike intervals in primary 
      auditory cortex.
PG  - 1908-17
LID - 10.1152/jn.01055.2010 [doi]
AB  - We analyzed the receptive field information conveyed by interspike intervals 
      (ISIs) in the auditory cortex. In the visual system, different ISIs may both code 
      for different visual features and convey differing amounts of stimulus 
      information. To determine their potential role in auditory signal processing, we 
      obtained extracellular recordings in the primary auditory cortex (AI) of the cat 
      while presenting a dynamic moving ripple stimulus and then used the responses to 
      construct spectrotemporal receptive fields (STRFs). For each neuron, we 
      constructed three STRFs, one for short-ISI events (ISI < 15 ms); one for 
      isolated, long-ISI events (ISI > 15 ms); and one including all events. To 
      characterize stimulus encoding, we calculated the feature selectivity and event 
      information for each of the STRFs. Short-ISI spikes were more feature selective 
      and conveyed information more efficiently. The different ISI regimens of AI 
      neurons did not represent different stimulus features, but short-ISI spike events 
      did contribute over-proportionately to the full spike train STRF information. 
      Thus short-ISIs constitute a robust representation of auditory features, and they 
      are particularly effective at driving postsynaptic activity. This suggests that 
      short-ISI events are especially suited to provide noise immunity and 
      high-fidelity information transmission in AI.
FAU - Shih, Jonathan Y
AU  - Shih JY
AD  - University of California, Berkeley, San Francisco Graduate Program in 
      Bioengineering, CA, USA. jshih@phy.ucsf.edu
FAU - Atencio, Craig A
AU  - Atencio CA
FAU - Schreiner, Christoph E
AU  - Schreiner CE
LA  - eng
GR  - P50 MH077970/MH/NIMH NIH HHS/United States
GR  - R01 DC002260/DC/NIDCD NIH HHS/United States
GR  - DC-02260/DC/NIDCD NIH HHS/United States
GR  - MH-077970/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110209
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - *Acoustic Stimulation
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Auditory Cortex/*physiology
MH  - Auditory Perception/*physiology
MH  - Cats
MH  - Cochlear Nerve/physiology
MH  - Models, Animal
MH  - Models, Neurological
MH  - Noise
MH  - Sensory Receptor Cells/physiology
MH  - Synaptic Transmission/physiology
PMC - PMC3075280
EDAT- 2011/02/11 06:00
MHDA- 2011/10/01 06:00
PMCR- 2012/04/01
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - jn.01055.2010 [pii]
AID - JN-01055-2010 [pii]
AID - 10.1152/jn.01055.2010 [doi]
PST - ppublish
SO  - J Neurophysiol. 2011 Apr;105(4):1908-17. doi: 10.1152/jn.01055.2010. Epub 2011 
      Feb 9.