PMID- 21307983
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1948-5182 (Electronic)
IS  - 1948-5182 (Print)
VI  - 3
IP  - 1
DP  - 2011 Jan 27
TI  - Multicentric occurrence of hepatocellular carcinoma with nonalcoholic 
      steatohepatitis.
PG  - 15-23
LID - 10.4254/wjh.v3.i1.15 [doi]
AB  - AIM: To reveal the manner of hepatocellular carcinoma (HCC) development in 
      patients with nonalcoholic steatohepatitis (NASH) focusing on multicentric 
      occurrence (MO) of HCC. METHODS: We compared clinicopathological characteristics 
      between patients with and without MO of HCC arising from NASH background. The 
      clinical features were implicated with reference to the literature available. 
      RESULTS: MO of HCC was identified with histological proof in 4 out of 12 patients 
      with NASH-related HCC (2 males and 2 females). One patient had synchronous MO; an 
      advanced HCC, two well-differentiated HCCs and a dysplastic nodule, followed by 
      the development of metachronous MO of HCC. The other three patients had multiple 
      advanced HCCs accompanied by a well-differentiated HCC or a dysplastic nodule. Of 
      these three patients, one had synchronous MO, one had metachronous MO and the 
      other had both synchronous and metachronous MO. There were no obvious differences 
      between the patients with or without MO in terms of liver function tests, tumor 
      markers and anatomical extent of HCC. On the other hand, all four patients with 
      MO of HCC were older than 70 years old and had the comorbidities of obesity, type 
      2 diabetes mellitus (T2DM), hypertension and cirrhosis. Although these conditions 
      were not limited to MO of HCC, all the conditions were met in only one of eight 
      patients without MO of HCC. Thus, concurrence of these conditions may be a 
      predisposing situation to synchronous MO of HCC. In particular, old age, T2DM and 
      cirrhosis were suggested to be prerequisite for MO because these factors were 
      depicted in common among two other cases with MO of HCC under NASH in the 
      literature. CONCLUSION: The putative predisposing factors and necessary 
      preconditions for synchronous MO of HCC in NASH were suggested in this study. 
      Further investigations are required to clarify the accurate prevalence and 
      predictors of MO to establish better strategies for treatment and prevention 
      leading to the prognostic improvement in NASH.
FAU - Kawai, Hirokazu
AU  - Kawai H
AD  - Hirokazu Kawai, Department of Clinical Laboratory, Niigata University Medical and 
      Dental Hospital, Niigata 951-8510, Japan.
FAU - Nomoto, Minoru
AU  - Nomoto M
FAU - Suda, Takeshi
AU  - Suda T
FAU - Kamimura, Kenya
AU  - Kamimura K
FAU - Tsuchiya, Atsunori
AU  - Tsuchiya A
FAU - Tamura, Yasushi
AU  - Tamura Y
FAU - Yano, Masahiko
AU  - Yano M
FAU - Takamura, Masaaki
AU  - Takamura M
FAU - Igarashi, Masato
AU  - Igarashi M
FAU - Wakai, Toshifumi
AU  - Wakai T
FAU - Yamagiwa, Satoshi
AU  - Yamagiwa S
FAU - Matsuda, Yasunobu
AU  - Matsuda Y
FAU - Ohkoshi, Shogo
AU  - Ohkoshi S
FAU - Kurosaki, Isao
AU  - Kurosaki I
FAU - Shirai, Yoshio
AU  - Shirai Y
FAU - Okada, Masahiko
AU  - Okada M
FAU - Aoyagi, Yutaka
AU  - Aoyagi Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Hepatol
JT  - World journal of hepatology
JID - 101532469
PMC - PMC3035698
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - Multicentric occurrence
OT  - Nonalcoholic steatohepatitis
EDAT- 2011/02/11 06:00
MHDA- 2011/02/11 06:01
PMCR- 2011/01/27
CRDT- 2011/02/11 06:00
PHST- 2010/09/03 00:00 [received]
PHST- 2010/11/11 00:00 [revised]
PHST- 2010/11/18 00:00 [accepted]
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/02/11 06:01 [medline]
PHST- 2011/01/27 00:00 [pmc-release]
AID - 10.4254/wjh.v3.i1.15 [doi]
PST - ppublish
SO  - World J Hepatol. 2011 Jan 27;3(1):15-23. doi: 10.4254/wjh.v3.i1.15.