PMID- 21308653
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20181023
IS  - 0003-9829 (Print)
IS  - 0003-9829 (Linking)
VI  - 148
IP  - 4
DP  - 2010 Dec
TI  - Ligation induced matrix-metalloproteinase-9 activity in peripheral frog nervous 
      system.
PG  - 397-403
LID - 10.4449/aib.v148i4.1133 [doi]
AB  - Matrix metalloproteinases (MMPs) are endopeptidases that cleave matrix, soluble 
      and membrane-bound proteins and are regulated by their endogenous inhibitors the 
      tissue inhibitors of MMPs (TIMPs). MMP-2 and MMP-9 are two of the MMPs which are 
      essential to contribute to inflammatory and degenerative processes in injured 
      nerves. The aim of the present study was to examine expression and activities of 
      MMP-2 and MMP-9 in the injured and control groups frog sciatic nerves using 
      gelatin zymography. Our investigation demonstrated for the first time as far as 
      we know the expression of MMP-2 and MMP-9 in frog sciatic nerve. The expression 
      and activity of MMP-9 were increased two fold on average following ligation. By 
      contrast, MMP-2 activities remained unchanged. These findings suggest that we can 
      consider MMP-9 as a marker for degenerative changes that follow nerve ligation in 
      frog nerve.
FAU - Banasr, Sihem
AU  - Banasr S
AD  - Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, Universite 
      de la Mediterranee, Marseille, France.
FAU - Sbai, Oualid
AU  - Sbai O
FAU - Ould-Yahoui, Adlane
AU  - Ould-Yahoui A
FAU - Gueye, Yatma
AU  - Gueye Y
FAU - Sakly, Mohsen
AU  - Sakly M
FAU - Abdelmelek, Hafedh
AU  - Abdelmelek H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Arch Ital Biol
JT  - Archives italiennes de biologie
JID - 0372441
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/physiology
MH  - Ligation/*methods
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Molecular Weight
MH  - Rana esculenta
MH  - Sciatic Nerve/*enzymology/injuries
EDAT- 2011/02/11 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.4449/aib.v148i4.1133 [doi]
PST - ppublish
SO  - Arch Ital Biol. 2010 Dec;148(4):397-403. doi: 10.4449/aib.v148i4.1133.