PMID- 21309732
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20220310
IS  - 1521-0499 (Electronic)
IS  - 0190-2148 (Linking)
VI  - 37
IP  - 4
DP  - 2011 May
TI  - Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with 
      antioxidative stress markers in chronic obstructive pulmonary disease.
PG  - 195-204
LID - 10.3109/01902148.2010.535093 [doi]
AB  - This study was undertaken to ascertain if a relationship existed between 
      oxidative status and polymorphisms of microsomal epoxide hydrolase X1 (EPHX1), 
      glutathione S-transferase P1 (GSTP1), GSTM1, and GSTT1 in chronic obstructive 
      pulmonary disease (COPD). Erythrocyte glutathione peroxidase (GSH-px), 
      glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and 
      plasma GST activities and total antioxidant status (TAS) as antioxidative stress 
      markers were determined and compared either with individual and combined 
      genotypes of EPHX1 exon 3, GSTP1 exon 5, GSTM1, and GSTT1 polymorphisms in COPD 
      patients and healthy controls from the central area of Tunisia. Statistical data 
      processing revealed significantly lower GSH-px, GR, SOD, CAT, GST, and TAS values 
      in COPD patients in comparison to the control group (P < .001). As for genotypes, 
      there was a no significant association in each of the 6 parameters and individual 
      genotypes (P > .05). A significant correlation between the studied parameters and 
      combined null GSTM1/null GSTT1 (GSH-px: P < .001, GR: P = .026, CAT: P = .018, 
      GST: P = .022, TAS: P = .046), His113His EPHX1/null GSTM1 (GSH-px: P = .001, GST: 
      P = .0012, TAS: P = .013), His113His EPHX1/Val105Val GSTP1 (GSH-px: P = .048, 
      CAT: P = .026, GST: P = .031), and null GSTM1/Val105Val GSTP1 (GSH-px: P = .011, 
      GR: P = .0028, GST: P = .0054, TAS: P = .032) was found in patients. In 
      conclusion, combined genetic polymorphisms of GSTM1, GSTT1, GSTP1, and EPHX1 may 
      have favorable effects on redox balance in COPD patients.
FAU - Lakhdar, Ramzi
AU  - Lakhdar R
AD  - Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, 
      Tunisia. lakhdarramzi@yahoo.fr
FAU - Denden, Sabri
AU  - Denden S
FAU - Mouhamed, Manel Haj
AU  - Mouhamed MH
FAU - Chalgoum, Abdelkader
AU  - Chalgoum A
FAU - Leban, Nadia
AU  - Leban N
FAU - Knani, Jalel
AU  - Knani J
FAU - Lefranc, Gerard
AU  - Lefranc G
FAU - Miled, Abelhadi
AU  - Miled A
FAU - Ben Chibani, Jemni
AU  - Ben Chibani J
FAU - Khelil, Amel Haj
AU  - Khelil AH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110211
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Biomarkers)
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (GSTP1 protein, human)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
RN  - EC 3.3.2.9 (EPHX1 protein, human)
SB  - IM
MH  - Biomarkers/analysis
MH  - Case-Control Studies
MH  - Epoxide Hydrolases/*genetics
MH  - Glutathione S-Transferase pi/genetics
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Oxidation-Reduction
MH  - Oxidative Stress/*genetics
MH  - *Polymorphism, Genetic
MH  - Pulmonary Disease, Chronic Obstructive/*genetics/metabolism
EDAT- 2011/02/12 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3109/01902148.2010.535093 [doi]
PST - ppublish
SO  - Exp Lung Res. 2011 May;37(4):195-204. doi: 10.3109/01902148.2010.535093. Epub 
      2011 Feb 11.