PMID- 21309736
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20211020
IS  - 1521-0499 (Electronic)
IS  - 0190-2148 (Print)
IS  - 0190-2148 (Linking)
VI  - 37
IP  - 5
DP  - 2011 Jun
TI  - Chronic allergen challenge induces pulmonary extramedullary hematopoiesis.
PG  - 279-90
LID - 10.3109/01902148.2010.540769 [doi]
AB  - Allergic inflammation is associated with increased generation and trafficking of 
      inflammatory cells, especially eosinophils, to sites of inflammation. The effect 
      of acute versus chronic airway allergen challenge on hematopoietic activity in 
      the bone marrow (BM) and lungs was investigated using murine models of allergic 
      airway inflammation. Acute allergen challenge induced proliferation of BM cells 
      and significantly increased generation of eosinophil, but not multipotent, 
      granulocyte-macrophage (GM), or B-lymphocyte progenitor cells. However, no 
      hematopoietic activity was observed in the lungs. With chronic challenge, BM 
      cells failed to proliferate, but exhibited increased capacity to generate 
      multipotent as well as eosinophil, GM, and B-lymphocyte progenitors. In addition, 
      increased generation of eosinophil- and GM-specific progenitors was observed in 
      the lungs. Although no differences were observed in their ability to roll on BM 
      endothelium in vitro or in vivo, CD34-enriched hematopoietic/stem progenitor 
      cells (HSPCs) from chronic-, but not acute-, challenged mice demonstrated reduced 
      migration across BM endothelial cells associated with decreased CXCR4 expression. 
      Overall, these studies demonstrate that chronic allergen exposure can alter BM 
      homing due to decreased transendothelial migration enabling noninteracting HSPCs 
      to egress out of the BM and recruit to sites of inflammation such as the airways, 
      resulting in extramedullary hematopoiesis.
FAU - Pandit, Terlika S
AU  - Pandit TS
AD  - Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and 
      Biomedical Sciences, University of Minnesota, St. Paul, Minnesota 55108, USA.
FAU - Hosseinkhani, M Reza
AU  - Hosseinkhani MR
FAU - Kang, Bit Na
AU  - Kang BN
FAU - Bahaie, Nooshin S
AU  - Bahaie NS
FAU - Ge, Xiao Na
AU  - Ge XN
FAU - Rao, Savita P
AU  - Rao SP
FAU - Sriramarao, P
AU  - Sriramarao P
LA  - eng
GR  - R01 AI035796/AI/NIAID NIH HHS/United States
GR  - R01 HL079304/HL/NHLBI NIH HHS/United States
GR  - R29 AI035796/AI/NIAID NIH HHS/United States
GR  - U19 AI070535/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20110211
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Allergens)
RN  - 0 (Antigens, CD34)
RN  - 0 (CXCR4 protein, mouse)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Allergens/administration & dosage/*immunology
MH  - Animals
MH  - Antigens, CD34/immunology
MH  - Cell Line
MH  - Cell Movement/immunology
MH  - Eosinophilia/immunology/metabolism
MH  - Eosinophils/immunology/metabolism
MH  - Hematopoiesis, Extramedullary/*immunology
MH  - Inflammation/*immunology/metabolism
MH  - Lung/*immunology/metabolism
MH  - Mice
MH  - Multipotent Stem Cells/immunology/metabolism
MH  - Myeloid Progenitor Cells/immunology/metabolism
MH  - Precursor Cells, B-Lymphoid/immunology/metabolism
MH  - Receptors, CXCR4/metabolism
PMC - PMC4086451
MID - NIHMS530776
EDAT- 2011/02/12 06:00
MHDA- 2011/09/03 06:00
PMCR- 2014/07/08
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
PHST- 2014/07/08 00:00 [pmc-release]
AID - 10.3109/01902148.2010.540769 [doi]
PST - ppublish
SO  - Exp Lung Res. 2011 Jun;37(5):279-90. doi: 10.3109/01902148.2010.540769. Epub 2011 
      Feb 11.