PMID- 21309994
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20211203
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 42
IP  - 5
DP  - 2012 May
TI  - Staphylococcus aureus bacteraemia at Alice Springs Hospital, Central Australia, 
      2003-2006.
PG  - 505-12
LID - 10.1111/j.1445-5994.2011.02449.x [doi]
AB  - BACKGROUND: Infectious diseases remain the leading cause of death at Alice 
      Springs Hospital (ASH) and Staphylococcus aureus bacteraemia (SAB) is the second 
      most common bloodstream infection. Non-multidrug-resistant, methicillin-resistant 
      S. aureus (nmMRSA) is endemic to the region. AIMS: To determine whether 
      differences exist between racial groups and resistance phenotypes in the clinical 
      manifestations and outcomes of SAB at ASH. METHODS: A retrospective review of 
      medical and pathology records for inpatients with SAB between 1 January 2003 and 
      31 December 2006. RESULTS: A total of 125 patients (indigenous, 111; 
      non-indigenous, 14) presented with SAB during the study period. Among indigenous 
      patients, there were 95 adults and 16 children. No non-indigenous child was 
      admitted with SAB. The mean annual incidence rate was 160.7/100 000 indigenous 
      population and 8.1/100 000 non-indigenous population (incidence rate ratio 19.9) 
      (P = 0.010). Isolates were predominantly methicillin-susceptible S. aureus 
      (indigenous, 85; non-indigenous, 13). Twenty of 27 MRSA isolates were 
      non-multidrug-resistant. Indigenous adults were more likely to present with an 
      infective focus (indigenous, 75; non-indigenous, 6) (P = 0.004). These were most 
      often skin infections (skin abscesses, 31; scabies, 4). Twenty-seven indigenous 
      adults self-discharged after receiving a median of only 5 days (inter-quartile 
      range (IQR), 3-9) of antibiotic therapy. Ninety-day mortality rates for 
      indigenous and non-indigenous adults were 14.7% and 14.3% respectively. The 
      median age of death for indigenous adults was 50 years (IQR, 37-68). CONCLUSIONS: 
      Indigenous Australians have the highest reported incidence rate of SAB worldwide. 
      This reflects the socioeconomic disadvantage experienced by indigenous 
      Australians whose living conditions predispose to pathogen transmission and 
      limits opportunities to maintain adequate skin hygiene.
CI  - (c) 2011 The Authors. Internal Medicine Journal (c) 2011 Royal Australasian College 
      of Physicians.
FAU - Hewagama, S
AU  - Hewagama S
AD  - Department of Medicine, Alice Springs Hospital, Alice Springs, Northern 
      Territory, Australia.
FAU - Spelman, T
AU  - Spelman T
FAU - Einsiedel, L J
AU  - Einsiedel LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bacteremia/*ethnology/therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Native Hawaiian or Other Pacific Islander/*ethnology
MH  - Northern Territory/ethnology
MH  - Retrospective Studies
MH  - Staphylococcal Infections/*ethnology/*therapy
MH  - *Staphylococcus aureus
MH  - Young Adult
EDAT- 2011/02/12 06:00
MHDA- 2013/07/09 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.1111/j.1445-5994.2011.02449.x [doi]
PST - ppublish
SO  - Intern Med J. 2012 May;42(5):505-12. doi: 10.1111/j.1445-5994.2011.02449.x.