PMID- 21310207
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20220410
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 49
IP  - 5
DP  - 2011 May
TI  - The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-alpha 
      and free fatty acids.
PG  - 1129-40
LID - 10.1016/j.fct.2011.02.004 [doi]
AB  - This study was conducted to investigate the effect of curcumin, obtained from 
      Curcuma longa, in comparison with rosiglitazone on the progression of insulin 
      resistance and type 2 diabetes mellitus (T2DM) and the mechanisms underlying this 
      effect. Insulin resistance and T2DM was induced in male Sprague Dawley rats by 
      high fat diet (HFD) feeding for 60 and for 75 days representing two regimens of 
      the study, protection and treatment. Prophylactic oral administration of curcumin 
      (80 mg/kg), rosiglitazone (1 mg/kg), their combination, or vehicle (in control 
      groups) was started along with HFD feeding in different groups. Treatment is 
      achieved by oral administration of the previously mentioned agents in the last 15 
      days of HFD feeding after induction of insulin resistance and T2DM in rats. 
      Curcumin showed an anti-hyperglycemic effect and improved insulin sensitivity, 
      and this action may be attributed at least in part to its anti-inflammatory 
      properties as evident by attenuating TNF-alpha levels in HFD fed rats, and its 
      anti-lipolytic effect as evident by attenuating plasma free fatty acids. The 
      curcumin effects are comparable to those of rosiglitazone, which indicate that 
      they may act similarly. Finally we can say that, curcumin could be a beneficial 
      adjuvant therapy in patients with T2DM.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - El-Moselhy, Mohamed A
AU  - El-Moselhy MA
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 
      Minia, Egypt.
FAU - Taye, Ashraf
AU  - Taye A
FAU - Sharkawi, Sara Shaaban
AU  - Sharkawi SS
FAU - El-Sisi, Suzan F I
AU  - El-Sisi SF
FAU - Ahmed, Ahmed Fahmy
AU  - Ahmed AF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110215
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Thiazolidinediones)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 05V02F2KDG (Rosiglitazone)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Administration, Oral
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Composition
MH  - Curcumin/*pharmacology
MH  - Diabetes Mellitus, Type 2/blood/metabolism
MH  - Dietary Fats/*administration & dosage
MH  - Fatty Acids, Nonesterified/*blood
MH  - Glucose Tolerance Test
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rosiglitazone
MH  - Thiazolidinediones/pharmacology
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2011/02/12 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/08/17 00:00 [received]
PHST- 2010/12/31 00:00 [revised]
PHST- 2011/02/01 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - S0278-6915(11)00035-4 [pii]
AID - 10.1016/j.fct.2011.02.004 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2011 May;49(5):1129-40. doi: 10.1016/j.fct.2011.02.004. Epub 
      2011 Feb 15.