PMID- 21310402
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20211020
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 111
IP  - 4
DP  - 2011 May
TI  - Uterine leiomyomata in a cohort of Great Lakes sport fish consumers.
PG  - 565-72
LID - 10.1016/j.envres.2011.01.006 [doi]
AB  - Diet and endocrine disrupting persistent organic pollutants (POPs) have been 
      associated with gynecologic conditions including uterine leiomyomata (UL), 
      endometriosis, and ovarian cysts. Great Lakes sport fish consumption is a source 
      of exposure to POPs such as p,p'-diphenyldichloroethene (DDE) and polychlorinated 
      biphenyls (PCBs). This study was designed to examine retrospectively the effects 
      Great Lakes sport fish consumption on the incidence of UL and to examine the 
      effects of DDE and PCB serum levels on prevalent UL in women participating in the 
      Great Lakes Fish Consumption Study. We hypothesized that associations of 
      exposures with UL would be modified by breastfeeding status. Years of sport fish 
      consumption, demographic, health, and reproductive data were assessed by survey. 
      In a subgroup, serum was collected and tested for DDE and PCB levels. Effects of 
      years of Great Lakes sport fish and sport fish consumption were modeled using 
      time-dependent Cox proportional hazards regression and effects of POP exposures 
      on UL were modeled using multiple logistic regression. Years of sport fish 
      consumption were associated with UL, with an incidence rate ratio of 1.2 (95% CI 
      1.0-1.3) for each 10-year increment of fish consumption. Summary measures of POP 
      exposures in the overall group were not associated with UL. In the subgroup of 
      women who never breastfed and in whom PCB measurements were available, however, 
      UL was significantly associated with PCBs and groupings of estrogenic, 
      antiestrogenic, and dioxin-like PCBs. These findings support the possibility that 
      PCB exposures from fish consumption may increase the risk of UL and highlight the 
      importance of additional studies exploring biologic pathways by which they could 
      be acting.
CI  - Published by Elsevier Inc.
FAU - Lambertino, Anissa
AU  - Lambertino A
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, 1603 W Taylor Street, Room 879, (M/C 923), Chicago, IL 
      60612, USA. alambe2@uic.edu
FAU - Turyk, Mary
AU  - Turyk M
FAU - Anderson, Henry
AU  - Anderson H
FAU - Freels, Sally
AU  - Freels S
FAU - Persky, Victoria
AU  - Persky V
LA  - eng
GR  - R21 ES017121/ES/NIEHS NIH HHS/United States
GR  - R21 ES017121-01A1/ES/NIEHS NIH HHS/United States
GR  - R21 ES017121-02/ES/NIEHS NIH HHS/United States
GR  - R21ES017121/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110209
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Water Pollutants, Chemical)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Diet/*statistics & numerical data
MH  - Environmental Exposure/statistics & numerical data
MH  - Female
MH  - Fisheries/*statistics & numerical data
MH  - Fishes/*blood
MH  - Great Lakes Region/epidemiology
MH  - Humans
MH  - Leiomyoma/blood/*epidemiology
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/blood
MH  - Uterine Neoplasms/blood/*epidemiology
MH  - Water Pollutants, Chemical/blood
PMC - PMC3111144
MID - NIHMS294291
EDAT- 2011/02/12 06:00
MHDA- 2011/06/23 06:00
PMCR- 2012/05/01
CRDT- 2011/02/12 06:00
PHST- 2010/07/29 00:00 [received]
PHST- 2010/12/21 00:00 [revised]
PHST- 2011/01/06 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - S0013-9351(11)00021-1 [pii]
AID - 10.1016/j.envres.2011.01.006 [doi]
PST - ppublish
SO  - Environ Res. 2011 May;111(4):565-72. doi: 10.1016/j.envres.2011.01.006. Epub 2011 
      Feb 9.