PMID- 21310403
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20161125
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 111
IP  - 4
DP  - 2011 May
TI  - Perfluorinated acids and hypothyroxinemia in pregnant women.
PG  - 559-64
LID - 10.1016/j.envres.2011.01.011 [doi]
AB  - Perfluorinated acids (PFAs) are prominent and widespread contaminants of human 
      blood. In animal studies there is evidence that suggests certain PFAs can disrupt 
      thyroid hormone homeostasis. A commonly reported condition in exposed animals is 
      hypothyroxinemia, whereby serum free thyroxine (fT4) is decreased despite normal 
      thyroid stimulating hormone (TSH) concentrations. We designed an individually 
      matched case-control study to investigate whether exposure to perfluorooctanoate 
      (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) 
      was associated with hypothyroxinemia in pregnant women from Edmonton, Alberta, 
      Canada, in 2005-2006, who underwent a "triple screen" blood test at 15-20 weeks 
      gestation as part of ante-natal care. Thyroid hormones, fT4 and TSH, were 
      measured in serum from 974 women, and from these we measured PFAs in the sera of 
      96 hypothyroxinemic cases (normal TSH, the lowest 10th percentile of fT4) and 175 
      controls (normal TSH, fT4 between the 50th and 90th percentiles) matched on age 
      and referring physician. Analyses by conditional logistic regression indicated 
      that the concentrations of PFAs in this population were not associated with 
      hypothyroxinemia among pregnant women. The current findings do not support a 
      causal link between PFA exposure and maternal hypothyroxinemia in the studied 
      population.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Chan, Emily
AU  - Chan E
AD  - Department of Public Health Sciences, School of Public Health, University of 
      Alberta, Edmonton, Alberta, Canada.
FAU - Burstyn, Igor
AU  - Burstyn I
FAU - Cherry, Nicola
AU  - Cherry N
FAU - Bamforth, Fiona
AU  - Bamforth F
FAU - Martin, Jonathan W
AU  - Martin JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110209
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
RN  - 355-46-4 (perfluorohexanesulfonic acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids/blood
MH  - Caprylates/blood/toxicity
MH  - Endocrine Disruptors/*blood/toxicity
MH  - Environmental Pollutants/*blood/toxicity
MH  - Female
MH  - Fluorocarbons/*blood/toxicity
MH  - Humans
MH  - Hypothyroidism/blood/*epidemiology
MH  - Maternal Exposure/statistics & numerical data
MH  - Middle Aged
MH  - Pregnancy
MH  - Sulfonic Acids/blood
MH  - Thyroxine/*blood
MH  - Young Adult
EDAT- 2011/02/12 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/07/28 00:00 [received]
PHST- 2011/01/07 00:00 [revised]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - S0013-9351(11)00026-0 [pii]
AID - 10.1016/j.envres.2011.01.011 [doi]
PST - ppublish
SO  - Environ Res. 2011 May;111(4):559-64. doi: 10.1016/j.envres.2011.01.011. Epub 2011 
      Feb 9.