PMID- 21312283
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20131121
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Mar
TI  - Postural sway approaches center of mass stability limits in Parkinson's disease.
PG  - 637-43
LID - 10.1002/mds.23547 [doi]
AB  - BACKGROUND: Although Parkinson's disease (PD) is a well recognised risk factor 
      for falls, how this disease and its therapy affect postural stability and leaning 
      balance remains unclear. The aim of this study was to examine the effects of PD 
      and levodopa on postural sway and leaning balance. METHODS: Performances of 28 PD 
      participants median [inter-quartile range (IQR)] duration of PD: 10 (6-13) 
      years, median (IQR) UPDRS motor score "off": 22 (14-31) "on" and "off" levodopa 
      were compared with 28 age- and gender-matched healthy controls on two measures of 
      controlled leaning balance [ratio of anterior-posterior (AP) sway to maximal 
      balance range (MBR) and coordinated stability]. RESULTS: PD participants had 
      greater ratio of AP sway to MBR than controls (P < 0.001), indicating that they 
      swayed more as a proportion of their limits of stability, both "off" and "on" 
      levodopa (P < 0.001). They also performed poorer in the coordinated stability 
      test both "off" and "on" levodopa compared to controls (P < 0.001, for both), 
      suggesting greater difficulty in controlling the center of mass at or near the 
      limits of stability. Levodopa improved PD "participants" leaning balance (P < 
      0.001) and reduced the AP sway to MBR ratio (P < 0.001), although not to the 
      level of controls. CONCLUSIONS: PD participants perform poorer than controls in 
      leaning balance tests but significantly improve when "on" levodopa. Regardless of 
      medication state, PD participants sway markedly more as a percentage of their 
      limits of stability than controls suggesting a higher risk of falling.
CI  - Copyright (c) 2011 Movement Disorder Society.
FAU - Menant, Jasmine C
AU  - Menant JC
AD  - Falls and Balance Research Group, Neuroscience Research Australia, Randwick, New 
      South Wales, Australia.
FAU - Latt, Mark D
AU  - Latt MD
FAU - Menz, Hylton B
AU  - Menz HB
FAU - Fung, Victor S
AU  - Fung VS
FAU - Lord, Stephen R
AU  - Lord SR
LA  - eng
PT  - Journal Article
DEP - 20110210
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Antiparkinson Agents)
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Aged
MH  - Antiparkinson Agents/therapeutic use
MH  - Female
MH  - Humans
MH  - Levodopa/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Muscle Rigidity/etiology
MH  - Neurologic Examination/methods
MH  - Parkinson Disease/*complications/drug therapy
MH  - Postural Balance/*physiology
MH  - Posture/*physiology
MH  - Reproducibility of Results
MH  - Sensation Disorders/drug therapy/*etiology
MH  - Statistics as Topic
EDAT- 2011/02/12 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/10/14 00:00 [revised]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 10.1002/mds.23547 [doi]
PST - ppublish
SO  - Mov Disord. 2011 Mar;26(4):637-43. doi: 10.1002/mds.23547. Epub 2011 Feb 10.