PMID- 21314968
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20220408
IS  - 1297-9716 (Electronic)
IS  - 0928-4249 (Print)
IS  - 0928-4249 (Linking)
VI  - 42
IP  - 1
DP  - 2011 Jan 18
TI  - Cytokine profiles and phenotype regulation of antigen presenting cells by 
      genotype-I porcine reproductive and respiratory syndrome virus isolates.
PG  - 9
LID - 10.1186/1297-9716-42-9 [doi]
AB  - The present study examined the immunological response of antigen presenting cells 
      (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome 
      virus (PRRSV) infection by analysing the cytokine profile induced and evaluating 
      the changes taking place upon infection on immunologically relevant cell markers 
      (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC 
      were infected with 39 PRRSV isolates. The results show that different isolates 
      were able to induce different patterns of IL-10 and TNF-alpha. The four possible 
      phenotypes based on the ability to induce IL-10 and/or TNF-alpha were observed, 
      although different cell types seemed to have different capabilities. In addition, 
      isolates inducing different cytokine-release profiles on APC could induce 
      different expression of cell markers.
FAU - Gimeno, Mariona
AU  - Gimeno M
AD  - Departament de Sanitat i d'Anatomia Animals, Facultat de Veterinaria, Universitat 
      Autonoma de Barcelona, 08193 Cerdanyola del Valles, Spain. 
      mariona.gimeno@cresa.uab.cat.
FAU - Darwich, Laila
AU  - Darwich L
FAU - Diaz, Ivan
AU  - Diaz I
FAU - de la Torre, Eugenia
AU  - de la Torre E
FAU - Pujols, Joan
AU  - Pujols J
FAU - Martin, Marga
AU  - Martin M
FAU - Inumaru, Shigeki
AU  - Inumaru S
FAU - Cano, Esmeralda
AU  - Cano E
FAU - Domingo, Mariano
AU  - Domingo M
FAU - Montoya, Maria
AU  - Montoya M
FAU - Mateu, Enric
AU  - Mateu E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110118
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/*immunology/metabolism
MH  - Cells, Cultured
MH  - Cytokines/biosynthesis/*metabolism
MH  - *Gene Expression Regulation
MH  - Phenotype
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Swine
PMC - PMC3037899
EDAT- 2011/02/15 06:00
MHDA- 2014/07/01 06:00
PMCR- 2011/01/01
CRDT- 2011/02/15 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/11/09 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 1297-9716-42-9 [pii]
AID - 10.1186/1297-9716-42-9 [doi]
PST - epublish
SO  - Vet Res. 2011 Jan 18;42(1):9. doi: 10.1186/1297-9716-42-9.