PMID- 21316444
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20211020
IS  - 1089-8646 (Electronic)
IS  - 0888-7543 (Linking)
VI  - 97
IP  - 6
DP  - 2011 Jun
TI  - Generalized F accelerated failure time model for mapping survival trait loci.
PG  - 379-85
LID - 10.1016/j.ygeno.2011.02.003 [doi]
AB  - As the two most popular models in survival analysis, the accelerated failure time 
      (AFT) model can more easily fit survival data than the Cox proportional hazards 
      model (PHM). In this study, we develop a general parametric AFT model for 
      identifying survival trait loci, in which the flexible generalized F 
      distribution, including many commonly used distributions as special cases, is 
      specified as the baseline survival distribution. EM algorithm for maximum 
      likelihood estimation of model parameters is given. Simulations are conducted to 
      validate the flexibility and the utility of the proposed mapping procedure. In 
      analyzing survival time following hyperoxic acute lung injury (HALI) of mice in 
      an F(2) mating population, the generalized F distribution performed best among 
      the six competing survival distributions and detected four QTLs controlling 
      differential HALI survival.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Zhou, Xiaojing
AU  - Zhou X
AD  - Department of Mathematics, Heilongjiang Bayi Agricultural University, Daqing, 
      People's Republic of China.
FAU - Yan, Li
AU  - Yan L
FAU - Prows, Daniel R
AU  - Prows DR
FAU - Yang, Runqing
AU  - Yang R
LA  - eng
GR  - R01 HL075562/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110226
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Acute Lung Injury/genetics/mortality
MH  - Algorithms
MH  - Animals
MH  - Bayes Theorem
MH  - Chromosome Mapping/*methods
MH  - Computer Simulation
MH  - Genetic Markers
MH  - Likelihood Functions
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Genetic
MH  - *Quantitative Trait Loci
MH  - *Survival Analysis
EDAT- 2011/02/15 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/10/20 00:00 [received]
PHST- 2011/01/13 00:00 [revised]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - S0888-7543(11)00022-X [pii]
AID - 10.1016/j.ygeno.2011.02.003 [doi]
PST - ppublish
SO  - Genomics. 2011 Jun;97(6):379-85. doi: 10.1016/j.ygeno.2011.02.003. Epub 2011 Feb 
      26.