PMID- 21318053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1868-7075 (Print)
IS  - 1868-7083 (Electronic)
IS  - 1868-7075 (Linking)
VI  - 1
IP  - 1-2
DP  - 2010 Sep 1
TI  - DNA hypermethylation markers of poor outcome in laryngeal cancer.
PG  - 61-69
AB  - This study examined molecular (DNA hypermethylation), clinical, 
      histopathological, demographical, smoking, and alcohol variables to assess 
      diagnosis (early versus late stage) and prognosis (survival) outcomes in a 
      retrospective primary laryngeal squamous cell carcinoma (LSCC) cohort. The study 
      cohort of 79 primary LSCC was drawn from a multi-ethnic (37% African American), 
      primary care patient population, diagnosed by surgical biopsies in the Henry Ford 
      Health System from 1991-2004, and followed from 5-18 years (through 2009). Of the 
      41 variables, univariate risk factors of p<0.10 were tested in multivariate 
      models (logistic regression diagnosis and Cox survival models p<0.05). 
      Aberrant methylation of ESR1 (p=0.01), race as African American (p=0.04), and 
      tumor necrosis (extensive) (p=0.02) were independent predictors of late stage 
      LSCC. Independent predictors of poor survival included presence of vascular 
      invasion (p=0.0009), late stage disease (p=0.03) and methylation of the HIC1 gene 
      (p=0.0002). Aberrant methylation of ESR1 and HIC1 signified independent markers 
      of poorer outcome. In this multi-ethnic, primary LSCC cohort, race remained a 
      predictor of late stage disease supporting disparate diagnosis outcomes for 
      African American patients with LSCC.
FAU - Stephen, Josena K
AU  - Stephen JK
AD  - Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, 
      MI, 48202.
FAU - Chen, Kang Mei
AU  - Chen KM
FAU - Shah, Veena
AU  - Shah V
FAU - Havard, Shaleta
AU  - Havard S
FAU - Kapke, Alissa
AU  - Kapke A
FAU - Lu, Mei
AU  - Lu M
FAU - Benninger, Michael S
AU  - Benninger MS
FAU - Worsham, Maria J
AU  - Worsham MJ
LA  - eng
GR  - R01 DE015990/DE/NIDCR NIH HHS/United States
GR  - R01 DE015990-05/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PL  - Germany
TA  - Clin Epigenetics
JT  - Clinical epigenetics
JID - 101516977
PMC - PMC3037188
MID - NIHMS239048
EDAT- 2011/02/15 06:00
MHDA- 2011/02/15 06:01
PMCR- 2010/06/24
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/02/15 06:01 [medline]
PHST- 2010/06/24 00:00 [pmc-release]
AID - 5 [pii]
AID - 10.1007/s13148-010-0005-3 [doi]
PST - ppublish
SO  - Clin Epigenetics. 2010 Sep 1;1(1-2):61-69. doi: 10.1007/s13148-010-0005-3.