PMID- 21318141
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Print)
IS  - 1687-8337 (Linking)
VI  - 2010
DP  - 2010
TI  - Primary hyperparathyroidism in patients with multiple endocrine neoplasia type 1.
PG  - 928383
LID - 10.1155/2010/928383 [doi]
LID - 928383
AB  - Primary hyperparathyroidism may occur as a part of an inherited syndrome in a 
      combination with pancreatic endocrine tumours and/or pituitary adenoma, which is 
      classified as Multiple Endocrine Neoplasia type 1 (MEN-1). This syndrome is 
      caused by a germline mutation in MEN-1 gene encoding a tumour-suppressor protein, 
      menin. Primary hyperparathyroidism is the most frequent clinical presentation of 
      MEN-1, which usually appears in the second decade of life as an asymptomatic 
      hypercalcemia and progresses through the next decades. The most frequent clinical 
      presentation of MEN-1-associated primary hyperparathyroidism is bone 
      demineralisation and recurrent kidney stones rarely followed by chronic kidney 
      disease. The aim of this paper is to present the pathomechanism, screening 
      procedures, diagnosis, and management of primary hyperparathyroidism in the MEN-1 
      syndrome. It also summarises the recent advances in the pharmacological therapy 
      with a new group of drugs-calcimimetics.
FAU - Piecha, Grzegorz
AU  - Piecha G
AD  - Department of Nephrology, Endocrinology and Metabolic Diseases, Medical 
      University of Silesia, ul. Francuska 20/24, 40-027 Katowice, Poland.
FAU - Chudek, Jerzy
AU  - Chudek J
FAU - Wiecek, Andrzej
AU  - Wiecek A
LA  - eng
PT  - Journal Article
DEP - 20110117
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC3034958
EDAT- 2011/02/15 06:00
MHDA- 2011/02/15 06:01
PMCR- 2011/01/17
CRDT- 2011/02/15 06:00
PHST- 2010/11/03 00:00 [received]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/02/15 06:01 [medline]
PHST- 2011/01/17 00:00 [pmc-release]
AID - 10.1155/2010/928383 [doi]
PST - ppublish
SO  - Int J Endocrinol. 2010;2010:928383. doi: 10.1155/2010/928383. Epub 2011 Jan 17.